Effects of meropenem exposure in persister cells of Acinetobacter calcoaceticus-baumannii

被引：11
|
作者：
Gallo, Stephanie Wagner [1 ]
Donamore, Bruna Kern [1 ]
Pagnussatti, Vany Elisa [2 ]
Sanchez Ferreira, Carlos Alexandre [1 ]
de Oliveira, Silvia Dias [1 ]
机构：
[1] Pontificia Univ Catolica Rio Grande do Sul PUCRS, Lab Imunol & Microbiol, Fac Biociencias, Porto Alegre, RS, Brazil
[2] Pontificia Univ Catolica Rio Grande do Sul PUCRS, Dept Microbiol, Lab Patol Clin, Hosp Sao Lucas, Porto Alegre, RS, Brazil
来源：
FUTURE MICROBIOLOGY | 2017年 / 12卷 / 02期
关键词：
carbapenems; chronic infections; persistence; therapeutic failure; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC TOLERANCE; MULTIDRUG TOLERANCE; OXIDATIVE STRESS; BIOFILMS; RESISTANCE; TARGET;
D O I：
10.2217/fmb-2016-0118
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: To evaluate the influence of meropenem in the Acinetobacter calcoaceticus-baumannii (ACB) persister levels. Methods: Persister levels in planktonic and biofilm cultures from ACB isolates were evaluated after exposure to different meropenem concentrations. Results: A high variability of persister fractions was observed among the isolates cultured under planktonic and biofilm conditions. Meropenem concentration did not influence persister fractions, even when far above the MIC. No correlation was found between persister levels and biofilm biomass. Conclusion: The magnitude of persister levels from ACB planktonic and, particularly, biofilm cultures exposed to meropenem was independent of the antibiotic concentration, dosing regimen and biofilm biomass. These findings, in a context of meropenem failure to treat chronic infections, strengthen the importance of understanding persister behavior.
引用
收藏
页码：131 / 140
页数：10
相关论文
共 50 条
  • [41] Endemic carbapenem-nonsusceptible Acinetobacter baumannii-calcoaceticus complex in intensive care units of the national referral hospital in Jakarta, Indonesia
    Saharman, Yulia Rosa
    Karuniawati, Anis
    Sedono, Rudyanto
    Aditianingsih, Dita
    Sudarmono, Pratiwi
    Goessens, Wil H. F.
    Klaassen, Corne H. W.
    Verbrugh, Henri A.
    Severin, Juliette A.
    ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL, 2018, 7
  • [42] Synergistic efficacy of meropenem and rifampicin in a murine model of sepsis caused by multidrug-resistant Acinetobacter baumannii
    Sun, Yuan
    Wang, Lei
    Li, Jiankang
    Zhao, Chongbo
    Zhao, Jinyi
    Liu, Meiyou
    Wang, Shan
    Lu, Chengtao
    Shang, Gangwei
    Jia, Yanyan
    Wen, Aidong
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 729 : 116 - 122
  • [43] In vitro pharmacokinetics/pharmacodynamics of the β-lactamase inhibitor, durlobactam, in combination with sulbactam against Acinetobacter baumannii-calcoaceticus complex
    O'Donnell, John
    Tanudra, Angela
    Chen, April
    Miller, Alita A.
    Mcleod, Sarah M.
    Tommasi, Ruben
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2024, 68 (01)
  • [44] Pharmacodynamic Effects of Sulbactam/Meropenem/Polymyxin-B Combination Against Extremely Drug Resistant Acinetobacter baumannii Using Checkerboard Information
    Menegucci, Thatiany Cevallos
    Fedrigo, Nayara Helisandra
    Lodi, Fernanda Gomes
    Albiero, James
    Belini Nishiyama, Sheila Alexandra
    Mazucheli, Josmar
    Carrara-Marroni, Floristher Elaine
    Voelkner, Nivea Maria Falcao
    Gong, Hui
    Sy, Sherwin K. B.
    Bronharo Tognim, Maria Cristina
    MICROBIAL DRUG RESISTANCE, 2019, 25 (09) : 1266 - 1274
  • [45] Comparison of 3 methods for determining sensitivity to imipenem and meropenem in Acinetobacter baumannii with a carbapenem-heteroresistant phenotype
    Fernandez-Cuenca, Felipe
    Egea, Pilar
    Lopez-Cerero, Lorena
    Alba, Paula Diaz-De
    Vila, Jordi
    Pascual, Alvaro
    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2008, 26 (08): : 485 - 488
  • [46] Role of Fibronectin in the Adhesion of Acinetobacter baumannii to Host Cells
    Smani, Younes
    McConnell, Michael J.
    Pachon, Jeronimo
    PLOS ONE, 2012, 7 (04):
  • [47] PCR Assay Based on the gyrB Gene for Rapid Identification of Acinetobacter baumannii-calcoaceticus Complex at Specie Level
    Teixeira, Aline B.
    Barin, Juliana
    Hermes, Djuli M.
    Barth, Afonso L.
    Martins, Andreza F.
    JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2017, 31 (03)
  • [48] Salmonella enterica persister cells form unstable small colony variants after in vitro exposure to ciprofloxacin
    Mattiello Drescher, Samara Paula
    Gallo, Stephanie Wagner
    Abreu Ferreira, Pedro Maria
    Sanchez Ferreira, Carlos Alexandre
    de Oliveira, Silvia Dias
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [49] Evaluating the antibacterial effect of meropenem-loaded chitosan/sodium tripolyphosphate (TPP) nanoparticles on Acinetobacter baumannii isolated from hospitalized patients
    Amini, Marziyeh Sadat
    Salehi, Majid Baseri
    Bahador, Nima
    BMC INFECTIOUS DISEASES, 2024, 24 (01)
  • [50] Biofilm Formation of Acinetobacter baumannii Under in vitro and in vivo Colistin Exposure
    Ozer, Berna
    Vatansever, Cansel
    Dogan, Ozlem
    Keske, Siran
    Ergonul, Onder
    Can, Fusun
    INFECTIOUS DISEASES AND CLINICAL MICROBIOLOGY, 2019, 1 (01): : 26 - 33
12345