TLR expression and NK cell activation after human yellow fever vaccination

被引：50

作者：

da Costa Neves, Patricia Cristina ^{[1
]}

de Souza Matos, Denise Cristina ^{[1
]}

Marcovistz, Rugimar ^{[1
]}

Galler, Ricardo ^{[1
]}

机构：

[1] Fundacao Oswaldo Cruz, Inst Tecnol Imunobiol, Lab Tecnol Imunol, BR-21040360 Rio De Janeiro, Brazil

来源：

VACCINE | 2009年 / 27卷 / 41期

关键词：

Yellow fever vaccine; Natural killer cells; Toll-like receptors; NATURAL-KILLER-CELLS; DENDRITIC CELLS; INNATE IMMUNITY; CYTOKINE PRODUCTION; CYTOTOXICITY; RESPONSES; RECEPTOR; VIRUS; 17D; MOLECULES;

D O I：

10.1016/j.vaccine.2009.07.028

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The yellow fever vaccine is very effective with a single injection conferring protection for at least 10 years. Recent evidence suggests that the innate immune cells activated through Toll-like receptors (TLRs), are critical determinants of the robustness of the adaptive response. Therefore, we investigated the NK cell status in eight healthy volunteers after vaccination with YF 17DD virus. Shortly after vaccination, we observed increased expression of TLR-3 and TLR-9 in NK cells and markers such as CD69, HLA-DP-DQ-DR, CD38 and CD16. The up-regulation of CD69 was positively correlated with the presence of TLRs; throughout the post-vaccination period and the circulating IFN-gamma was significantly augmented. These results suggest that TLRs may play an important role in NK cell activation during the immune response to vaccination, indicating a potential role for NK cells in helping the development of long-lasting protective memory. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5543 / 5549

页数：7

共 48 条

[1] NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease [J].