Intestinal epithelial barrier function and tight junction proteins with heat and exercise

被引：253

作者：

Dokladny, Karol ^{[1
]}

Zuhl, Micah N. ^{[2
]}

Moseley, Pope L. ^{[1
,3
]}

机构：

[1] Univ New Mexico, Hlth Sci Ctr, Hlth Exercise & Sports Sci, Dept Internal Med, Albuquerque, NM 87131 USA

[2] Cent Michigan Univ, Sch Hlth Sci, Mt Pleasant, MI 48859 USA

[3] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Prot Res, DK-1168 Copenhagen, Denmark

来源：

JOURNAL OF APPLIED PHYSIOLOGY | 2016年 / 120卷 / 06期

关键词：

intestinal epithelial barrier; heat shock response; HSP70; exercise; INDUCED GASTROINTESTINAL PERMEABILITY; ORAL GLUTAMINE SUPPLEMENTATION; TUMOR-NECROSIS-FACTOR; OCCLUDIN PHOSPHORYLATION; BACTERIAL TRANSLOCATION; INCREASES SURVIVAL; STRESSED PRIMATES; IMPROVES SURVIVAL; BOVINE COLOSTRUM; OXIDATIVE STRESS;

D O I：

10.1152/japplphysiol.00536.2015

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

A single layer of enterocytes and tight junctions (intercellular multiprotein complexes) form the intestinal epithelial barrier that controls transport of molecules through transcellular and paracellular pathways. A dysfunctional or "leaky" intestinal tight junction barrier allows augmented permeation of luminal antigens, endotoxins, and bacteria into the blood stream. Various substances and conditions have been shown to affect the maintenance of the intestinal epithelial tight junction barrier. The primary focus of the present review is to analyze the effects of exertional or nonexertional (passive hyperthermia) heat stress on tight junction barrier function in in vitro and in vivo (animals and humans) models. Our secondary focus is to review changes in tight junction proteins in response to exercise or hyperthermic conditions. Finally, we discuss some pharmacological or nutritional interventions that may affect the cellular mechanisms involved in maintaining homeostasis of the intestinal epithelial tight junction barrier during heat stress or exercise.

引用

页码：692 / 701

页数：10

共 97 条

[91] Interferon-γ and tumor necrosis factor-α synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression [J].

Wang, FJ ;

Graham, WV ;

Wang, YM ;

Witkowski, ED ;

Schwarz, BT ;

Turner, JR .

AMERICAN JOURNAL OF PATHOLOGY, 2005, 166 (02) :409-419

[92] ENDOTOXEMIA IN ACTIVE CROHNS-DISEASE - TREATMENT WITH WHOLE GUT IRRIGATION AND 5-AMINOSALICYLIC ACID [J].

WELLMANN, W ;

FINK, PC ;

BENNER, F ;

SCHMIDT, FW .

GUT, 1986, 27 (07) :814-820

[93] Protein interactions at the tight junction - Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3 [J].

Wittchen, ES ;

Haskins, J ;

Stevenson, BR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (49) :35179-35185

[94] Eicosapentaenoic Acid Enhances Heat Stress-Impaired Intestinal Epithelial Barrier Function in Caco-2 Cells [J].

Xiao, Guizhen ;

Tang, Liqun ;

Yuan, Fangfang ;

Zhu, Wei ;

Zhang, Shaoheng ;

Liu, Zhifeng ;

Geng, Yan ;

Qiu, Xiaowen ;

Zhang, Yali ;

Su, Lei .

PLOS ONE, 2013, 8 (09)

[95] Investigation into the signal transduction pathway via which heat stress impairs intestinal epithelial barrier function [J].

Yang, Ping-Chang ;

He, Shao-Heng ;

Zheng, Peng-Yuan .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2007, 22 (11) :1823-1831

[96] The effects of acute oral glutamine supplementation on exercise-induced gastrointestinal permeability and heat shock protein expression in peripheral blood mononuclear cells [J].

Zuhl, Micah ;

Dokladny, Karol ;

Mermier, Christine ;

Schneider, Suzanne ;

Salgado, Roy ;

Moseley, Pope .

CELL STRESS & CHAPERONES, 2015, 20 (01) :85-93

[97] Effects of oral glutamine supplementation on exercise-induced gastrointestinal permeability and tight junction protein expression [J].

Zuhl, Micah N. ;

Lanphere, Kathryn R. ;

Kravitz, Len ;

Mermier, Christine M. ;

Schneider, Suzanne ;

Dokladny, Karol ;

Moseley, Pope L. .

JOURNAL OF APPLIED PHYSIOLOGY, 2014, 116 (02) :183-191

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