Seroprevalence of antibodies against fHbp and NadA, two potential vaccine antigens for Neisseria meningitidis

被引：12
|
作者：
Jacobsson, Susanne [1 ]
Molling, Paula [1 ]
Olcen, Per [1 ]
机构：
[1] Orebro Univ Hosp, Dept Lab Med, Natl Reference Lab Pathogen Neisseria, SE-70185 Orebro, Sweden
来源：
VACCINE | 2009年 / 27卷 / 42期
关键词：
Neisseria meningitidis; Factor H binding protein (fHbp); Neisseria adhesin A (NadA); Seroprevalence; Vaccine; SEROGROUP-B MENINGOCOCCUS; INFLUENZAE TYPE-B; ESCHERICHIA-COLI; CONJUGATE VACCINES; NATURAL IMMUNITY; SERUM ANTIBODIES; ADHESIN-A; DISEASE; POLYSACCHARIDE; CANDIDATE;
D O I：
10.1016/j.vaccine.2009.07.056
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The IgG antibody levels directed against fHbp and NadA, two potential vaccine antigens for Neisseria meningitidis, were examined in order to investigate the extent of natural immunisation against these antigens in different age groups. As a comparison, the IgG antibody levels against Haemophilus influenzae type b were examined. In the two youngest age groups, below 10 years of age, relatively low levels of both anti-fHbp and anti-NadA were measured. A 15-fold higher geometric mean concentration of anti-fHbp was noted in the age group 20-29 years as compared to the age group 15-19 years. The peak concentration was found at 30-39 years, followed by decreased levels with age. Anti-NadA showed a certain increase up to 9 years followed by an even increase up to 40-49 years. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5755 / 5759
页数：5
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