Antibiofouling, Sustained Antibiotic Release by Si Nanowire Templates

被引：56

作者：

Brammer, Karla S. ^{[1
]}

Choi, Chulmin ^{[1
]}

Oh, Seunghan ^{[1
,2
]}

Cobb, Christine J. ^{[1
]}

Connelly, Laura S. ^{[1
]}

Loya, Mariana ^{[1
]}

Kong, Seong Deok ^{[1
]}

Jin, Sungho ^{[1
]}

机构：

[1] Univ Calif San Diego, La Jolla, CA 92093 USA

[2] Wonkwang Univ, Coll Dent, Dept Dent Biomat, Iksan, Jeollabookdo, South Korea

来源：

NANO LETTERS | 2009年 / 9卷 / 10期

关键词：

DRUG-DELIVERY DEVICES; POROUS SILICON; IN-VITRO; SYSTEMS; ARRAYS; BIOCOMPATIBILITY; FABRICATION; MICROCHIP; IMPLANTS; CELLS;

D O I：

10.1021/nl901769m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Loading or filling nanostructures with antibiotics can be one of the relevant approaches for obtaining a controlled drug release rate. Vertically aligned silicon nanowire (SiNW) arrays with 10-40 nm diameter wires having 1-3 mu m in length obtained by the electroless etching (EE) technique are used in this study as novel nanostructures for mediating drug delivery. Here we report controlled antibiotic activity and sustained bioavailability from SiNW arrays and also show microstructural manipulations for a tunable release rate, As well, we have demonstrated biodegradability of SiNWs in phosphate buffer saline (PBS) solution. Strikingly suppressed cell and protein adhesion was observed on our SiNW surface, which indicates a reduced probability for biofouling and drug release Impediments. Such antibiotic release from the nanowire-structured surface can provide more reliable antibiotic protection at a targeted implantation or biosensor site.

引用

页码：3570 / 3574

页数：5

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[21]

2-E

[22] In vitro and in vivo release of ciprofloxacin from PLGA 50:50 implants [J].