The in vitro Antimicrobial Activity and Chemometric Modelling of 59 Commercial Essential Oils against Pathogens of Dermatological Relevance

被引：44

作者：

Orchard, Ane ^{[1
]}

Sandasi, Maxleene ^{[2
]}

Kamatou, Guy ^{[2
]}

Viljoen, Alvaro ^{[2
,3
]}

van Vuuren, Sandy ^{[1
]}

机构：

[1] Univ Witwatersrand, Dept Pharm & Pharmacol, Fac Hlth Sci, 7 York Rd, ZA-2193 Parktown, South Africa

[2] Tshwane Univ Technol, Dept Pharmaceut Sci, Fac Sci, Private Bag X680, ZA-0001 Pretoria, South Africa

[3] Tshwane Univ Technol, Dept Pharmaceut Sci, SAMRC Herbal Drugs Res Unit, ZA-0001 Pretoria, South Africa

来源：

CHEMISTRY & BIODIVERSITY | 2017年 / 14卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Essential oil; Eugenol; Skin diseases; Acne; Dermatophyte; Infection; Antimicrobial activities; TEA TREE OIL; CLOVE ESSENTIAL OIL; ANTIFUNGAL ACTIVITY; CHEMICAL-COMPOSITION; ANTIBACTERIAL PROPERTIES; BREVIBACTERIUM-CASEI; L; ANTIOXIDANT; AGENTS; ENDOCARDITIS;

D O I：

10.1002/cbdv.201600218

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study reports on the inhibitory concentration of 59 commercial essential oils recommended for dermatological conditions, and identifies putative compounds responsible for antimicrobial activity. Essential oils were investigated for antimicrobial activity using minimum inhibitory concentration assays. Ten essential oils were identified as having superior antimicrobial activity. The essential oil compositions were determined using gas chromatography coupled to mass spectrometry and the data analysed with the antimicrobial activity using multivariate tools. Orthogonal projections to latent structures models were created for seven of the pathogens. Eugenol was identified as the main biomarker responsible for antimicrobial activity in the majority of the essential oils. The essential oils mostly displayed noteworthy antimicrobial activity, with five oils displaying broad-spectrum activity against the 13 tested micro-organisms. The antimicrobial efficacies of the essential oils highlight their potential in treating dermatological infections and through chemometric modelling, bioactive volatiles have been identified.

引用

页数：18

共 88 条

[81] Comparative Study on the Antioxidant Capacity and Cholinesterase Inhibitory Activity of Citrus aurantifolia Swingle, C. aurantium L., and C. bergamia Risso and Poit. Peel Essential Oils [J].