Effects of the Bark Resin Extract of Garcinia nigrolineata on Chronic Stress-Induced Memory Deficit in Mice Model and the In Vitro Monoamine Oxidases and β-Amyloid Aggregation Inhibitory Activities of Its Prenylated Xanthone Constituents

被引：5

作者：

Khamphukdee, Charinya ^{[1
]}

Turkmani, Ibrahim ^{[2
,3
]}

Chotritthirong, Yutthana ^{[4
]}

Chulikhit, Yaowared ^{[5
]}

Boonyarat, Chantana ^{[5
]}

Sekeroglu, Nazim ^{[6
,7
]}

Silva, Artur M. S. ^{[8
,9
]}

Monthakantirat, Orawan ^{[5
]}

Kijjoa, Anake ^{[2
,3
]}

机构：

[1] Khon Kaen Univ, Fac Pharmaceut Sci, Div Pharmacognosy & Toxicol, Khon Kaen 40002, Thailand

[2] Univ Porto, ICBAS Inst Ciencias Biomed Abel Salazar, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

[3] Univ Porto, CIIMAR, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

[4] Khon Kaen Univ, Grad Sch Pharmaceut Sci, Khon Kaen 40002, Thailand

[5] Khon Kaen Univ, Fac Pharmaceut Sci, Div Pharmaceut Chem, Khon Kaen 40002, Thailand

[6] Gaziantep Univ, Fac Arts & Sci, Phytotherapy Med & Aromat Plants Applicat & Res C, TR-27310 Gaziantep, Turkey

[7] Gaziantep Univ, Fac Arts & Sci, Biol Dept, TR-27310 Gaziantep, Turkey

[8] Univ Aveiro, Dept Quim, P-3810193 Aveiro, Portugal

[9] Univ Aveiro, QOPNA, P-3810193 Aveiro, Portugal

来源：

MOLECULES | 2022年 / 27卷 / 09期

关键词：

Garcinia nigrolineata; prenylated xanthones; unpredictable chronic mild stress (UCMS); memory deficit; monoamine oxidases; beta-amyloid aggregation; MORRIS WATER MAZE; CHRONIC MILD STRESS; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; DERIVATIVES; HIPPOCAMPAL; IMPAIRMENT;

D O I：

10.3390/molecules27093014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study describes investigation of the effects of the bark resin extract of Garcinia nigrolineata (Clusiaceae) on the cognitive function and the induction of oxidative stress in both frontal cortex and hippocampus by unpredictable chronic mild stress (UCMS). By using behavioral mouse models, i.e., the Y-maze test, the Novel Object Recognition Test (NORT), and the Morris Water Maze Test (MWMT), it was found that the negative impact of repeated mild stress-induced learning and memory deficit through brain oxidative stress in the UCMS mice was reversed by treatment with the bark resin extract G. nigrolineata. Moreover, the prenylated xanthones viz. cowagarcinone C, cowaxanthone, alpha-mangostin, cowaxanthone B, cowanin, fuscaxanthone A, fuscaxanthone B, xanthochymusxanthones A, 7-O-methylgarcinone E, and cowagarcinone A, isolated from the bark resin of G. nigrolineata, were assayed for their inhibitory activities against beta-amyloid (A beta) aggregation and monoamine oxidase enzymes (MAOs).

引用

页数：17