Microwave-assisted multicomponent reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and their corresponding 2(1H)-thiones using lanthanum oxide as a catalyst under solvent-free conditions

被引：20

作者：

Kuraitheerthakumaran, A. ^{[1
]}

Pazhamalai, S. ^{[1
]}

Gopalakrishnan, M. ^{[1
]}

机构：

[1] Annamalai Univ, Dept Chem, Annamalainagar 608002, Tamil Nadu, India

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2016年 / 9卷

关键词：

3,4-Dihydropyrimidinone; Lanthanum oxide; Biginelli reaction; Microwave; Solvent-free; ONE-POT SYNTHESIS; BIGINELLI REACTION; SCANDIUM TRIFLUOROMETHANESULFONATE; REUSABLE CATALYST; ORGANIC-SYNTHESIS; TRIFLATE; ACID; 3,4-DIHYDROPYRIMIDINE-2(1H)-ONES; DIHYDROPYRIMIDINONES; EFFICIENT;

D O I：

10.1016/j.arabjc.2011.06.005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of 3,4-dihydropyrimidinone derivatives using lanthanum oxide as a catalyst, from aldehydes, beta-keto ester and urea/thiourea without solvent under the irradiation of microwave is described. Compared with classical Biginelli reaction conditions, this new method has the advantage of excellent yields and shorter reaction times. (C) 2011 Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：S461 / S465

页数：5

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