Assessing cancer risks of low-dose radiation

被引：169

作者：

Mullenders, Leon ^{[1
]}

Atkinson, Mike ^{[2
,3
]}

Paretzke, Herwig ^{[4
]}

Sabatier, Laure ^{[5
]}

Bouffler, Simon ^{[6
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Toxicogenet, NL-2300 RC Leiden, Netherlands

[2] Helmholtz Ctr Munich, Inst Radiat Biol, D-85764 Munich, Germany

[3] Tech Univ Munich, Klinikum Rechts Isar, Dept Radiat Oncol, D-8000 Munich, Germany

[4] Helmholtz Ctr Munich, Inst Radiat Protect, D-85764 Munich, Germany

[5] Atom Res Ctr, Div Life Sci, F-92265 Fontenay Aux Roses, France

[6] Hlth Protect Agcy, Radiat Protect Div, Chilton OX11 0RQ, England

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 08期

关键词：

ATOMIC-BOMB SURVIVORS; DOUBLE-STRAND BREAKS; IONIZING-RADIATION; DNA-DAMAGE; IN-VIVO; GENE-EXPRESSION; HYPER-RADIOSENSITIVITY; TELOMERE DYSFUNCTION; HUMAN-CELLS; INTERVENTIONAL RADIOLOGY;

D O I：

10.1038/nrc2677

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ionizing radiation is considered a non-threshold carcinogen. However, quantifying the risk of the more commonly encountered low and/or protracted radiation exposures remains problematic and subject to uncertainty. Therefore, a major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis. This Perspective article considers whether differences exist between the effects mediated by high- and low-dose radiation exposure and how this affects the assessment of low-dose cancer risk.

引用

页码：596 / U89

页数：9

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