Regulation of PAR-1 in patients undergoing percutaneous coronary intervention: effects of unfractionated heparin and bivalirudin

被引：19

作者：

Eslam, Roza Badr ^{[2
]}

Reiter, Nina ^{[1
]}

Kaider, Alexandra ^{[3
]}

Eichinger, Sabine ^{[4
]}

Lang, Irene M. ^{[1
]}

Panzer, Simon ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Blood Grp Serol & Transfus Med, Div Blood Grp Serol, Vienna, Austria

[2] Med Univ Vienna, Dept Internal Med 2, Div Cardiol, Vienna, Austria

[3] Med Univ Vienna, Core Unit Med Stat & Informat, Sect Clin Biometr, Vienna, Austria

[4] Med Univ Vienna, Dept Internal Med 1, Div Haematol & Haemostaseol, Vienna, Austria

来源：

EUROPEAN HEART JOURNAL | 2009年 / 30卷 / 15期

关键词：

Bivalirudin; Heparin; Platelets; PAR-1; Thrombin; Percutaneous coronary intervention; PROTEASE-ACTIVATED RECEPTORS; PLATELET ACTIVATION; GLYCOPROTEIN-IB; THROMBIN; AGGREGATION; CLOPIDOGREL; STRATEGY; PATHWAY; TRIAL;

D O I：

10.1093/eurheartj/ehp186

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined the specific effects of unfractionated heparin and bivalirudin on thrombin-inducible platelet PAR-1 in patients undergoing percutaneous coronary intervention (PCI). To simulate in vivo conditions that may precipitate a bleeding event, we added thrombin in vitro to blood samples from 89 patients who had been randomly assigned to receive heparin or bivalirudin for elective PCI and examined thrombin-inducible PAR-1 expression. Thrombin-inducible cleavage of PAR-1 was inhibited by heparin, but not affected by bivalirudin (P = 0.0001). Further, PAR-1 internalization was more effectively inhibited by heparin than bivalirudin (P = 0.002). Heparin has stronger inhibitory effects on thrombin-dependent PAR-1 cleavage and internalization, thus providing a biological explanation for lower clinical bleeding rates with bivalirudin.

引用

收藏

页码：1831 / 1836

页数：6

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