Spermidine-induced improvement of memory consolidation involves PI3K/Akt signaling pathway

被引:9
|
作者
Fabbrin, Shaiana Beck [1 ]
Girardi, Bruna Amanda [1 ]
Wendel, Arithane de Lorena [2 ]
Ilha Valin, Carolina Coelho [2 ]
Pillat, Micheli Mainardi [3 ]
Viero, Fernanda Tibolla [3 ]
Mello, Carlos Fernando [3 ]
Rubin, Maribel Antonello [1 ,3 ]
机构
[1] Univ Fed Santa Maria, Ctr Exact & Nat Sci, Grad Program Biol Sci Toxicol Biochem, BR-97105900 Santa Maria, RS, Brazil
[2] Univ Fed Santa Maria, Ctr Hlth Sci, Sch Pharm, BR-97105900 Santa Maria, RS, Brazil
[3] Univ Fed Santa Maria, Ctr Hlth Sci, Grad Program Pharmacol, BR-97105900 Santa Maria, RS, Brazil
关键词
Memory; Consolidation; Polyamines; Hippocampus; BDNF; Akt; INHIBITORY AVOIDANCE PERFORMANCE; FEAR MEMORY; PHOSPHOINOSITIDE; 3-KINASE; SYNAPTIC PLASTICITY; NMDA RECEPTORS; PROTEIN-KINASE; HIPPOCAMPUS; ACQUISITION; PERSISTENCE; MODULATION;
D O I
10.1016/j.brainresbull.2020.08.018
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Spermidine (SPD) is an endogenous polyamine that plays a facilitatory role in memory acquisition and consolidation. Memory consolidation occurs immediately after learning and again around 3-6 hours later. Current evidence indicates that the polyamine binding site at the NMDA receptor (NMDAr) mediates the effects of SPD on memory. While NMDAr activation increases brain-derived neurotrophic factor (BDNF) release, no study has investigated whether BDNF-activated signaling pathways, such as the phosphatidylinositol 3-kinase (PI3K)/Akt pathway play a role in SPD-induced improvement of memory consolidation. Therefore, the aim of the current study was to evaluate whether the TrkB receptor and the PI3K/Akt pathway are involved in the facilitatory effect of SPD on memory consolidation. Male Wistar rats were trained in the contextual conditioned fear task. SPD, ANA-12 (TrkB antagonist), and LY294002 (PI3K inhibitor) were administered immediately after training. The animals were tested 24 h after training. We found that SPD improved fear memory consolidation and that both ANA-12 and LY294002 prevented the facilitatory effect of SPD on memory. These results suggest that SPD-induced improvement of memory consolidation involves the activation of the TrkB receptor and PI3K/Akt pathway.
引用
收藏
页码:208 / 213
页数:6
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