In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes

被引：49
作者：
Dannaoui, Eric [1 ,2 ]
Schwarz, Patrick [1 ]
Lortholary, Olivier [1 ,3 ]
机构：
[1] Inst Pasteur, CNRS, URA3012, Unite Mycol Mol,Ctr Natl Reference Mycol & Antifo, F-75724 Paris 15, France
[2] Univ Paris 05, Hop Europeen Georges Pompidou, AP HP, Fac Med,Unite Parasitol Mycol, Paris, France
[3] Univ Paris 05, Hop Necker Enfants Malad, AP HP, Serv Malad Infect & Trop,Fac Med,Ctr Infect Necke, Paris, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 08期
关键词：
ERGOSTEROL BIOSYNTHESIS INHIBITORS; ORGAN TRANSPLANT RECIPIENTS; CANDIDA-ALBICANS; CRYPTOCOCCUS-NEOFORMANS; CALCINEURIN INHIBITORS; AMPHOTERICIN-B; CYCLOSPORINE-A; COMBINATION; FLUCONAZOLE; CASPOFUNGIN;
D O I：
10.1128/AAC.00184-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro interaction of antifungals with immunosuppressive drugs was evaluated against zygomycetes. The combination of amphotericin B with cyclosporine, rapamycin, or tacrolimus was synergistic for 90%, 70%, and 30% of the isolates, respectively. For posaconazole, itraconazole, and ravuconazole, synergy was more frequently observed with cyclosporine than with rapamycin or tacrolimus and antagonistic interactions were rarely noted. In summary, calcineurin inhibitors and rapamycin can be synergistic in vitro with amphotericin B and azoles against zygomycetes.
引用
收藏
页码：3549 / 3551
页数：3
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