A new experimental design for screening Chinese medicine formula

被引：11

作者：

Tang, CH

Wang, BC ^{[1
]}

Chen, Q

Zhou, L

Cai, SX

机构：

[1] Chongqing Univ, Bioengn Coll, Key Lab Biomech & Tissue Engn, State Minist Educ, Chongqing 400044, Peoples R China

[2] Chongqing Business & Technol Univ, Dept Bioengn, Chongqing 400033, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2004年 / 36卷 / 02期

关键词：

orthogonal experimental design; uniform experimental design; traditional Chinese medicine formula; screening;

D O I：

10.1016/j.colsurfb.2004.05.013

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

In this paper, an appropriate scale screening for traditional Chinese medicine formula was developed in according to verified pharmacological experiments with uniform optimized experimental design and orthogonal optimized experimental design. Meanwhile, a most appropriate match of prescription dosage for curing vascular disease was got, which was based on NO value of pharmacodynamics experimental data and the endothelial cells configuration which would changed in a degree when damaged by hydration diamine. The appropriate scale of the formula was Ginkgo extraction: substance A:B:C = 100:20:50:0.01. This formula was more optimized and effective than other formula compared by pharmacological and validated experiments. (C) 2004 Elsevier B.V All rights reserved.

引用

页码：105 / 109

页数：5

共 14 条

[1]

CHUNHUA Y, 1999, J EMERG MED, V8, P160

[2] Simultaneous spectrophotometric determination of rutin, quercetin and ascorbic acid in drugs using a Kalman Filter approach [J].

Hassan, HNA ;

Barsoum, BN ;

Habib, IHI .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1999, 20 (1-2) :315-320

[3]

HUI C, 2001, STRAIT PHARM J, V13, P13

[4]

Kaitai F., 1994, UNIFORM DESIGN UNIFO, P19

[5] Optimization of fabrication conditions of high-efficiency ultrafiltration membranes using methods of uniform design and regression analysis [J].

Leung, SYL ;

Chan, WH ;

Luk, CH .

CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2000, 53 (1-2) :21-35

[6]

Leung SYL, 1998, CHEMOMETR INTELL LAB, V40, P203

[7] Uniform design method for optimization of process parameters of plasma sprayed TiN coatings [J].

Li, JF ;

Liao, H ;

Normand, B ;

Cordier, C ;

Maurin, G ;

Foct, J ;

Coddet, C .

SURFACE & COATINGS TECHNOLOGY, 2003, 176 (01) :1-13

[8] The influence of operational variables on mean size and size distribution of spheroids produced by rotary spheronization using teardrop studs [J].

Liew, CV ;

Gu, L ;

Heng, PWS .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 242 (1-2) :345-348

[9]

MIN LW, 2001, CHIN J EXP TRADITION, V2, P18

[10]

PENG G, 2003, CHIN TRADITIONAL HER, V2, P123

← 1 2 →