Thee-component, one-pot synthesis of hexahydroazepino [3,4-b]indole and tetrahydro-1H-pyrido[3,4-b]indole derivatives and evaluation of their cytotoxicity

被引：26

作者：

Reddy, B. V. Subba ^{[1
]}

Ganesh, A. Venkata ^{[1
]}

Vani, M. ^{[1
]}

Murthy, T. Ramalinga ^{[2
]}

Kalivendi, Shasi V. ^{[2
]}

Yadav, J. S. ^{[1
]}

机构：

[1] CSIR, Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

[2] CSIR, Indian Inst Chem Technol, Ctr Chem Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 18期

关键词：

3CC Ugi reaction; Aldehydo acid; Aryl amine; Isonitrile; Azepinones; Pyrido[3,4-b]indoles; UGI; 3CC; MULTICOMPONENT REACTIONS; DESIGN;

D O I：

10.1016/j.bmcl.2014.07.084

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A three-component, four-center Ugi reaction has been developed to produce a novel class of 2-aryl-3-oxo-hexahydroazepino[3,4-b]indole and 2-aryl-3-oxo-tetrahydro-1H-pyrido[3,4-b]indole derivatives in good to high yields. A few of them exhibit moderate cytotoxicity against various cancer cell lines such as HeLa (human epithelial cervical cancer), A549 (human lung carcinoma epithelial), DU145 (human prostate carcinoma epithelial) and MCF-7 (human breast adenocarcinoma). (C) 2014 Published by Elsevier Ltd.

引用

页码：4501 / 4503

页数：3

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