The regulatory role of long noncoding RNAs in cancer

被引：99

作者：

Tang, Ying ^{[1
,2
]}

Cheung, Belamy B. ^{[1
]}

Atmadibrata, Bernard ^{[1
]}

Marshall, Glenn M. ^{[1
]}

Dinger, Marcel E. ^{[3
,4
]}

Liu, Pei Y. ^{[1
]}

Liu, Tao ^{[1
,5
]}

机构：

[1] Childrens Canc Inst Australia Med Res, Sydney, NSW 2031, Australia

[2] Kunming Med Univ, Elect Microscopy Lab, 1168 Chunrongxi Rd, Kunming, Yunnan, Peoples R China

[3] Garvan Inst Med Res, Darlinghurst, NSW 2010, Australia

[4] UNSW Australia, UNSW Med, St Vincents Clin Sch, Darlinghurst, NSW 2010, Australia

[5] UNSW Australia, UNSW Ctr Childhood Canc Res, Sydney, NSW 2052, Australia

来源：

CANCER LETTERS | 2017年 / 391卷

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

Long noncoding RNA; Gene expression; Cancer; HEPATOCELLULAR-CARCINOMA; TARGETED THERAPY; DIPHTHERIA-TOXIN; OVARIAN-CANCER; UP-REGULATION; GENE; H19; EXPRESSION; CHROMATIN; TRANSCRIPTION;

D O I：

10.1016/j.canlet.2017.01.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With the advances in genomic analysis technologies, especially next-generation RNA sequencing, a large number of new transcripts have been discovered, leading to better understanding of long noncoding RNAs (IncRNAs). Recent investigations have provided firm evidence for the critical roles of IncRNAs in chromatin modification, gene transcription, RNA splicing, RNA transport and translation. In vitro and in vivo studies have also proven that aberrant lncRNA expression is essential for the initiation and progression of cancers. Due to their unique tissue- and cancer-specific expression profiles, aberrant expression of IncRNAs can be used as reliable prognostic markers for cancer diagnoses and treatment stratification, and lncRNAs are novel therapeutic targets with high therapeutic windows. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：12 / 19

页数：8

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