The Treatment of Plasmodium knowlesi Malaria

被引：41

作者：

Barber, Bridget E. ^{[1
,2
,3
]}

Grigg, Matthew J. ^{[1
,2
,3
]}

William, Timothy ^{[3
,4
,5
]}

Yeo, Tsin W. ^{[1
,2
,3
,6
,7
]}

Anstey, Nicholas M. ^{[1
,2
,3
]}

机构：

[1] Menzies Sch Hlth Res, POB 41096, Casuarina, NT 0810, Australia

[2] Charles Darwin Univ, POB 41096, Casuarina, NT 0810, Australia

[3] Infect Dis Soc Sabah Menzies Sch Hlth Res, Clin Res Unit, Kota Kinabalu 88586, Sabah, Malaysia

[4] Queen Elizabeth Hosp, Clin Res Ctr, Kota Kinabalu 88586, Sabah, Malaysia

[5] Jesselton Med Ctr, Kota Kinabalu 88300, Sabah, Malaysia

[6] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 639798, Singapore

[7] Tan Tock Seng Hosp, Inst Infect Dis & Epidemiol, Communicable Dis Ctr, Singapore 308433, Singapore

来源：

TRENDS IN PARASITOLOGY | 2017年 / 33卷 / 03期

基金：

英国医学研究理事会;

关键词：

VIVO DRUG SUSCEPTIBILITY; SEVERE FALCIPARUM-MALARIA; INCREASING INCIDENCE; HIGH PROPORTION; MONKEY MALARIA; OPEN-LABEL; TRAVELER; SABAH; MALAYSIA; CHLOROQUINE;

D O I：

10.1016/j.pt.2016.09.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Plasmodium knowlesi occurs across Southeast Asia and is the most common cause of malaria in Malaysia. High parasitaemias can develop rapidly, and the risk of severe disease in adults is at least as high as in falciparum malaria. Prompt initiation of effective treatment is therefore essential. Intravenous artesunate is highly effective in severe knowlesi malaria and in those with moderately high parasitaemia but otherwise uncomplicated disease. Both chloroquine and artemisinin-combination therapy (ACT) are highly effective for uncomplicated knowlesi malaria, with faster parasite clearance times and lower anaemia rates with ACT. Given the difficulties with microscope diagnosis of P. knowlesi, a unified treatment strategy of ACT for all Plasmodium species is recommended in coendemic regions.

引用

页码：242 / 253

页数：12

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