One-Pot Regiospecific Synthesis of Imidazo[1,2-a]pyridines: A Novel, Metal-Free, Three-Component Reaction for the Formation of C-N, C-O, and C-S Bonds

被引：125

作者：

Cao, Hua ^{[1
]}

Liu, Xiaohang ^{[2
]}

Zhao, Limin ^{[1
]}

Cen, Jinghe ^{[1
]}

Lin, Jingxin ^{[1
]}

Zhu, Qiuxia ^{[1
]}

Fu, Minling ^{[1
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China

[2] BASF Catalyst, Beachwood, OH 44124 USA

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ELECTRON-DEFICIENT ALKYNES; COUPLING REACTION; DIRECT ARYLATION; REGIOSELECTIVE SYNTHESIS; MULTICOMPONENT REACTION; DOMINO PROCESS; SOLVENT-FREE; AMINATION; OXIDATION; ACCESS;

D O I：

10.1021/ol4031414

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel transition-metal-free three-component reaction for the construction of imidazo[1,2-c]pyridines has been developed. It represents a facile approach for the formation of C-N, C-O, and C-S bonds from ynals, pyridin-2-amines, and alcohols or thiols.

引用

页码：146 / 149

页数：4

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