One-Pot Regiospecific Synthesis of Imidazo[1,2-a]pyridines: A Novel, Metal-Free, Three-Component Reaction for the Formation of C-N, C-O, and C-S Bonds

被引：125
|
作者：
Cao, Hua [1 ]
Liu, Xiaohang [2 ]
Zhao, Limin [1 ]
Cen, Jinghe [1 ]
Lin, Jingxin [1 ]
Zhu, Qiuxia [1 ]
Fu, Minling [1 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China
[2] BASF Catalyst, Beachwood, OH 44124 USA
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 01期
基金：
中国国家自然科学基金;
关键词：
ELECTRON-DEFICIENT ALKYNES; COUPLING REACTION; DIRECT ARYLATION; REGIOSELECTIVE SYNTHESIS; MULTICOMPONENT REACTION; DOMINO PROCESS; SOLVENT-FREE; AMINATION; OXIDATION; ACCESS;
D O I：
10.1021/ol4031414
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel transition-metal-free three-component reaction for the construction of imidazo[1,2-c]pyridines has been developed. It represents a facile approach for the formation of C-N, C-O, and C-S bonds from ynals, pyridin-2-amines, and alcohols or thiols.
引用
收藏
页码：146 / 149
页数：4
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