Function of an N-heterocyclic carbene ligand based on concept of chiral mimetic

被引：35

作者：

Arao, Takafumi ^{[1
]}

Sato, Kei ^{[1
]}

Kondo, Kazuhiro ^{[1
]}

Aoyama, Toyohiko ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 11期

关键词：

optically active N-heterocyclic carbene ligand; chiral mimetic; imidazolium salt; asymmetric arylation;

D O I：

10.1248/cpb.54.1576

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Function of a new N-heterocyclic carbene ligand based on the concept of a chiral mimetic is described. With (4R,5R)-4,5-diphenyl-1,3-dialkyl-4,5-dihydro-3H-imidazol-1-ium tetrafluoroborates as N-heterocyclic carbene precursors, Rh-catalyzed enantioselective arylation (up to 27% ee) of aromatic aldehydes with arylboronic acids and Pd-catalyzed enantioselective intramolecular alpha-arylation (up to 66% ee) of N-(2-bromoaryl)-N-alkyl-2-arylpropanamides are investigated.

引用

页码：1576 / 1581

页数：6

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