Sodium-glucose cotransporter 2 inhibition and cardiovascular risk reduction in patients with type 2 diabetes: the emerging role of natriuresis

被引：96

作者：

Rajasekeran, Harindra ^{[1
]}

Lytvyn, Yuliya ^{[1
,2
]}

Cherney, David Z. I. ^{[1
]}

机构：

[1] Univ Toronto, Toronto Gen Hosp, Dept Med, Div Nephrol, Toronto, ON M5G 1L7, Canada

[2] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

来源：

KIDNEY INTERNATIONAL | 2016年 / 89卷 / 03期

关键词：

URIC-ACID; EMPAGLIFLOZIN;

D O I：

10.1016/j.kint.2015.12.038

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Inhibition of sodium-glucose cotransporter 2 causes both glycosuria and natriuresis, leading to reductions in hyperglycemia, body weight, blood pressure, and proteinuria. The recently published EMPA-REG OUTCOME study demonstrated significant cardiovascular and mortality benefits of sodium-glucose cotransporter 2 inhibition with empagliflozin in patients with type 2 diabetes and established cardiovascular disease, and may suggest a broader role for sodium-glucose cotransporter 2 inhibition in patients with heart failure.

引用

页码：524 / 526

页数：4

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