共 90 条
Production of recombinant proteins in plant cells
被引:7
作者:

Gerasimova, S. V.
论文数: 0 引用数: 0
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机构:
Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Fed Res Ctr, Pr Akad Lavrentyeva 10, Novosibirsk 630090, Russia
Novosibirsk State Univ, Ul Pirogova 2, Novosibirsk 630090, Russia Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Fed Res Ctr, Pr Akad Lavrentyeva 10, Novosibirsk 630090, Russia

Smirnova, O. G.
论文数: 0 引用数: 0
h-index: 0
机构:
Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Fed Res Ctr, Pr Akad Lavrentyeva 10, Novosibirsk 630090, Russia
Novosibirsk State Univ, Ul Pirogova 2, Novosibirsk 630090, Russia Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Fed Res Ctr, Pr Akad Lavrentyeva 10, Novosibirsk 630090, Russia

Kochetov, A. V.
论文数: 0 引用数: 0
h-index: 0
机构:
Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Fed Res Ctr, Pr Akad Lavrentyeva 10, Novosibirsk 630090, Russia
Novosibirsk State Univ, Ul Pirogova 2, Novosibirsk 630090, Russia Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Fed Res Ctr, Pr Akad Lavrentyeva 10, Novosibirsk 630090, Russia

Shumnyi, V. K.
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h-index: 0
机构:
Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Fed Res Ctr, Pr Akad Lavrentyeva 10, Novosibirsk 630090, Russia
Novosibirsk State Univ, Ul Pirogova 2, Novosibirsk 630090, Russia Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Fed Res Ctr, Pr Akad Lavrentyeva 10, Novosibirsk 630090, Russia
机构:
[1] Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Fed Res Ctr, Pr Akad Lavrentyeva 10, Novosibirsk 630090, Russia
[2] Novosibirsk State Univ, Ul Pirogova 2, Novosibirsk 630090, Russia
基金:
俄罗斯基础研究基金会;
关键词:
higher plants;
recombinant protein;
glycosylation;
promoter;
vector;
affinity tag;
biotechnology;
HIGH-LEVEL PRODUCTION;
HIGH-YIELD PRODUCTION;
MONOCLONAL-ANTIBODY;
EXPRESSION SYSTEMS;
N-GLYCOSYLATION;
TOBACCO CELLS;
PURIFICATION;
TRANSLATION;
PLATFORM;
FUSIONS;
D O I:
10.1134/S1021443716010076
中图分类号:
Q94 [植物学];
学科分类号:
071001 ;
摘要:
Vegetable protein synthesis systems for industry, medicine, and research are becoming increasingly popular. The technology of protein production in plants has certain advantages, compared with the expression systems of bacteria and yeast. The rich variety of promoters, regulatory elements, affinity tags, and fusion partners that are used in molecular biology and plant biotechnology can create hybrid genetic constructs adapted to the solution of various tasks associated with protein synthesis and purification. New methods of modification of plant systems are being developed for the synthesis of functionally active human proteins whose structure is close to the natural analogues. This review shows current approaches to increase the yield of the target protein, facilitating the procedures of its isolation and purification and preventing degradation.
引用
收藏
页码:26 / 37
页数:12
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共 90 条
[1]
Expression of the affinity tags, glutathione-S-transferase and maltose-binding protein, in tobacco chloroplasts
[J].
Ahmad, Niaz
;
Michoux, Franck
;
McCarthy, James
;
Nixon, Peter J.
.
PLANTA,
2012, 235 (04)
:863-871

Ahmad, Niaz
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, London SW7 2AZ, England

Michoux, Franck
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, London SW7 2AZ, England

McCarthy, James
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Rech Nestle, F-37097 Tours, France Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, London SW7 2AZ, England

Nixon, Peter J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, London SW7 2AZ, England
[2]
The dynamic behavior of storage organelles in developing cereal seeds and its impact on the production of recombinant proteins
[J].
Arcalis, Elsa
;
Ibl, Verena
;
Peters, Jenny
;
Melnik, Stanislav
;
Stoger, Eva
.
FRONTIERS IN PLANT SCIENCE,
2014, 5

Arcalis, Elsa
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Nat Resources & Life Sci, Dept Appl Genet & CellBiol, A-1190 Vienna, Austria Univ Nat Resources & Life Sci, Dept Appl Genet & CellBiol, A-1190 Vienna, Austria

Ibl, Verena
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Nat Resources & Life Sci, Dept Appl Genet & CellBiol, A-1190 Vienna, Austria Univ Nat Resources & Life Sci, Dept Appl Genet & CellBiol, A-1190 Vienna, Austria

Peters, Jenny
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Nat Resources & Life Sci, Dept Appl Genet & CellBiol, A-1190 Vienna, Austria Univ Nat Resources & Life Sci, Dept Appl Genet & CellBiol, A-1190 Vienna, Austria

Melnik, Stanislav
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Nat Resources & Life Sci, Dept Appl Genet & CellBiol, A-1190 Vienna, Austria Univ Nat Resources & Life Sci, Dept Appl Genet & CellBiol, A-1190 Vienna, Austria

Stoger, Eva
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Nat Resources & Life Sci, Dept Appl Genet & CellBiol, A-1190 Vienna, Austria Univ Nat Resources & Life Sci, Dept Appl Genet & CellBiol, A-1190 Vienna, Austria
[3]
Unintended molecular interactions in transgenic plants expressing clinically useful proteins: The case of bovine aprotinin traveling the potato leaf cell secretory pathway
[J].
Badri, M. Amine
;
Rivard, Daniel
;
Coenen, Karine
;
Michaud, Dominique
.
PROTEOMICS,
2009, 9 (03)
:746-756

Badri, M. Amine
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, Dept Phytol, INAF, CRH,Pavillon Serv, Quebec City, PQ G1V 0A6, Canada Univ Laval, Dept Phytol, INAF, CRH,Pavillon Serv, Quebec City, PQ G1V 0A6, Canada

Rivard, Daniel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, Dept Phytol, INAF, CRH,Pavillon Serv, Quebec City, PQ G1V 0A6, Canada Univ Laval, Dept Phytol, INAF, CRH,Pavillon Serv, Quebec City, PQ G1V 0A6, Canada

Coenen, Karine
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, Dept Phytol, INAF, CRH,Pavillon Serv, Quebec City, PQ G1V 0A6, Canada Univ Laval, Dept Phytol, INAF, CRH,Pavillon Serv, Quebec City, PQ G1V 0A6, Canada

Michaud, Dominique
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, Dept Phytol, INAF, CRH,Pavillon Serv, Quebec City, PQ G1V 0A6, Canada Univ Laval, Dept Phytol, INAF, CRH,Pavillon Serv, Quebec City, PQ G1V 0A6, Canada
[4]
Oleosin di-or tri-meric fusions with GFP undergo correct targeting and provide advantages for recombinant protein production
[J].
Banilas, Georgios
;
Daras, Gerasimos
;
Rigas, Stamatis
;
Moloney, Maurice M.
;
Hatzopoulos, Polydefkis
.
PLANT PHYSIOLOGY AND BIOCHEMISTRY,
2011, 49 (02)
:216-222

Banilas, Georgios
论文数: 0 引用数: 0
h-index: 0
机构:
Agr Univ Athens, Dept Agr Biotechnol, Athens 11855, Greece Agr Univ Athens, Dept Agr Biotechnol, Athens 11855, Greece

Daras, Gerasimos
论文数: 0 引用数: 0
h-index: 0
机构:
Agr Univ Athens, Dept Agr Biotechnol, Athens 11855, Greece Agr Univ Athens, Dept Agr Biotechnol, Athens 11855, Greece

Rigas, Stamatis
论文数: 0 引用数: 0
h-index: 0
机构:
Agr Univ Athens, Dept Agr Biotechnol, Athens 11855, Greece Agr Univ Athens, Dept Agr Biotechnol, Athens 11855, Greece

Moloney, Maurice M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada Agr Univ Athens, Dept Agr Biotechnol, Athens 11855, Greece

Hatzopoulos, Polydefkis
论文数: 0 引用数: 0
h-index: 0
机构:
Agr Univ Athens, Dept Agr Biotechnol, Athens 11855, Greece Agr Univ Athens, Dept Agr Biotechnol, Athens 11855, Greece
[5]
Preventing unintended proteolysis in plant protein biofactories
[J].
Benchabane, Meriem
;
Goulet, Charles
;
Rivard, Daniel
;
Faye, Loic
;
Gomord, Veronique
;
Michaud, Dominique
.
PLANT BIOTECHNOLOGY JOURNAL,
2008, 6 (07)
:633-648

Benchabane, Meriem
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, Dept Phytol, CHR INAF, Quebec City, PQ G1K 7P4, Canada Univ Laval, Dept Phytol, CHR INAF, Quebec City, PQ G1K 7P4, Canada

Goulet, Charles
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, Dept Phytol, CHR INAF, Quebec City, PQ G1K 7P4, Canada Univ Laval, Dept Phytol, CHR INAF, Quebec City, PQ G1K 7P4, Canada

Rivard, Daniel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, Dept Phytol, CHR INAF, Quebec City, PQ G1K 7P4, Canada Univ Laval, Dept Phytol, CHR INAF, Quebec City, PQ G1K 7P4, Canada

Faye, Loic
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rouen, CNRS UMR 6037, IFRMP 23, Fac Sci, F-76821 Mont St Aignan, France Univ Laval, Dept Phytol, CHR INAF, Quebec City, PQ G1K 7P4, Canada

Gomord, Veronique
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Rouen, CNRS UMR 6037, IFRMP 23, Fac Sci, F-76821 Mont St Aignan, France Univ Laval, Dept Phytol, CHR INAF, Quebec City, PQ G1K 7P4, Canada

Michaud, Dominique
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Laval, Dept Phytol, CHR INAF, Quebec City, PQ G1K 7P4, Canada Univ Laval, Dept Phytol, CHR INAF, Quebec City, PQ G1K 7P4, Canada
[6]
Use of oil bodies and oleosins in recombinant protein production and other biotechnological applications
[J].
Bhatla, S. C.
;
Kaushik, V.
;
Yadav, M. K.
.
BIOTECHNOLOGY ADVANCES,
2010, 28 (03)
:293-300

Bhatla, S. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Delhi, Dept Bot, Delhi 110007, India Univ Delhi, Dept Bot, Delhi 110007, India

Kaushik, V.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Delhi, Dept Bot, Delhi 110007, India Univ Delhi, Dept Bot, Delhi 110007, India

Yadav, M. K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Delhi, Dept Bot, Delhi 110007, India Univ Delhi, Dept Bot, Delhi 110007, India
[7]
Genetic engineering of the chloroplast: novel tools and new applications
[J].
Bock, Ralph
.
CURRENT OPINION IN BIOTECHNOLOGY,
2014, 26
:7-13

Bock, Ralph
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Pflanzenphysiol, D-14476 Potsdam, Germany Max Planck Inst Mol Pflanzenphysiol, D-14476 Potsdam, Germany
[8]
Seed-based expression systems for plant molecular farming
[J].
Boothe, Joseph
;
Nykiforuk, Cory
;
Shen, Yin
;
Zaplachinski, Steven
;
Szarka, Steven
;
Kuhlman, Philip
;
Murray, Elizabeth
;
Morck, Douglas
;
Moloney, Maurice M.
.
PLANT BIOTECHNOLOGY JOURNAL,
2010, 8 (05)
:588-606

Boothe, Joseph
论文数: 0 引用数: 0
h-index: 0
机构:
SemBioSys Genet Inc, Calgary, AB, Canada SemBioSys Genet Inc, Calgary, AB, Canada

Nykiforuk, Cory
论文数: 0 引用数: 0
h-index: 0
机构:
SemBioSys Genet Inc, Calgary, AB, Canada SemBioSys Genet Inc, Calgary, AB, Canada

Shen, Yin
论文数: 0 引用数: 0
h-index: 0
机构:
SemBioSys Genet Inc, Calgary, AB, Canada SemBioSys Genet Inc, Calgary, AB, Canada

Zaplachinski, Steven
论文数: 0 引用数: 0
h-index: 0
机构:
SemBioSys Genet Inc, Calgary, AB, Canada SemBioSys Genet Inc, Calgary, AB, Canada

Szarka, Steven
论文数: 0 引用数: 0
h-index: 0
机构:
SemBioSys Genet Inc, Calgary, AB, Canada SemBioSys Genet Inc, Calgary, AB, Canada

Kuhlman, Philip
论文数: 0 引用数: 0
h-index: 0
机构:
SemBioSys Genet Inc, Calgary, AB, Canada SemBioSys Genet Inc, Calgary, AB, Canada

Murray, Elizabeth
论文数: 0 引用数: 0
h-index: 0
机构:
SemBioSys Genet Inc, Calgary, AB, Canada SemBioSys Genet Inc, Calgary, AB, Canada

Morck, Douglas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada SemBioSys Genet Inc, Calgary, AB, Canada

Moloney, Maurice M.
论文数: 0 引用数: 0
h-index: 0
机构:
SemBioSys Genet Inc, Calgary, AB, Canada
Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada SemBioSys Genet Inc, Calgary, AB, Canada
[9]
N-Glycosylation of Plant-produced Recombinant Proteins
[J].
Bosch, Dirk
;
Castilho, Alexandra
;
Loos, Andreas
;
Schots, Arjen
;
Steinkellner, Herta
.
CURRENT PHARMACEUTICAL DESIGN,
2013, 19 (31)
:5503-5512

Bosch, Dirk
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wageningen & Res Ctr, Plant Res Int, NL-6708 PB Wageningen, Netherlands
Univ Utrecht, Dept Chem, NL-3584 CH Utrecht, Netherlands Univ Wageningen & Res Ctr, Plant Res Int, NL-6708 PB Wageningen, Netherlands

Castilho, Alexandra
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Nat Resources & Life Sci, Dept Appl Genet & Cell Biol, A-1190 Vienna, Austria Univ Wageningen & Res Ctr, Plant Res Int, NL-6708 PB Wageningen, Netherlands

Loos, Andreas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Nat Resources & Life Sci, Dept Appl Genet & Cell Biol, A-1190 Vienna, Austria Univ Wageningen & Res Ctr, Plant Res Int, NL-6708 PB Wageningen, Netherlands

Schots, Arjen
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wageningen & Res Ctr, Dept Plant Sci, Nematol Lab, NL-6708 PB Wageningen, Netherlands Univ Wageningen & Res Ctr, Plant Res Int, NL-6708 PB Wageningen, Netherlands

Steinkellner, Herta
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Nat Resources & Life Sci, Dept Appl Genet & Cell Biol, A-1190 Vienna, Austria Univ Wageningen & Res Ctr, Plant Res Int, NL-6708 PB Wageningen, Netherlands
[10]
Plant glycans: friend or foe in vaccine development?
[J].
Bosch, Dirk
;
Schots, Arjen
.
EXPERT REVIEW OF VACCINES,
2010, 9 (08)
:835-842

Bosch, Dirk
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wageningen & Res Ctr, Dept Plant Sci, Nematol Lab, NL-6708 PB Wageningen, Netherlands
Univ Utrecht, Dept Chem, NL-3584 CH Utrecht, Netherlands Univ Wageningen & Res Ctr, Dept Plant Sci, Nematol Lab, NL-6708 PB Wageningen, Netherlands

Schots, Arjen
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wageningen & Res Ctr, Dept Plant Sci, Nematol Lab, NL-6708 PB Wageningen, Netherlands Univ Wageningen & Res Ctr, Dept Plant Sci, Nematol Lab, NL-6708 PB Wageningen, Netherlands