Identification of inhibitors for UDP-galactopyranose mutase

被引：86

作者：

Soltero-Higgin, M

Carlson, EE

Phillips, JH

Kiessling, LL

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 34期

关键词：

D O I：

10.1021/ja048017v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The flavoenzyme uridine 5′-diphosphate (UDP)-galactopyranose mutase (UGM) plays a key role in the cell wall biosynthesis of many pathogens, including Mycobacterium tuberculosis. Using a synthetic fluorescent ligand, we screened 16000 compounds in a fluorescence polarization assay. Effective inhibitors of UGM were identified. Copyright © 2004 American Chemical Society.

引用

收藏

页码：10532 / 10533

页数：2

相关论文

共 20 条

[1] 4-thiazolidinones: Novel inhibitors of the bacterial enzyme MurB [J].

Andres, CJ ;

Bronson, JJ ;

D'Andrea, SV ;

Deshpande, MS ;

Falk, PJ ;

Grant-Young, KA ;

Harte, WE ;

Ho, HT ;

Misco, PF ;

Robertson, JG ;

Stock, D ;

Sun, YX ;

Walsh, AW .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (08) :715-717

[2] The mycobacterial cell envelope: A target for novel drugs against tuberculosis [J].

Besra, GS ;

Brennan, PJ .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1997, 49 :25-30

[3] Biosynthesis of the arabinogalactan-peptidoglycan complex of Mycobacterium tuberculosis [J].

Crick, DC ;

Mahapatra, S ;

Brennan, PJ .

GLYCOBIOLOGY, 2001, 11 (09) :107R-118R

[4] Highly efficient chemoenzymatic synthesis of α-galactosyl epitopes with a recombinant α(1→3)-galactosyltransferase [J].

Fang, JW ;

Li, J ;

Chen, X ;

Zhang, YN ;

Wang, JQ ;

Guo, ZM ;

Zhang, W ;

Yu, LB ;

Brew, K ;

Wang, PG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (27) :6635-6638

[5] Identification of active-site inhibitors of MurG using a generalizable, high-throughput glycosyltransferase screen [J].

Helm, JS ;

Hu, YN ;

Chen, L ;

Gross, B ;

Walker, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (37) :11168-11169

[6]

KANG UG, 1975, J BIOL CHEM, V250, P7099

[7]

KIESSLING LL, 2003, ACS MNEW YORK CITY S

[8] UDP-galactofuranose precursor required for formation of the lipopolysaccharide O antigen of Klebsiella pneumoniae serotype 01 is synthesized by the product of the rfbD(KP01) gene [J].

Koplin, R ;

Brisson, JR ;

Whitfield, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (07) :4121-4128

[9] Interactions with aromatic rings in chemical and biological recognition [J].

Meyer, EA ;

Castellano, RK ;

Diederich, F .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (11) :1210-1250

[10] Galactofuranose biosynthesis in Escherichia coli K-12: Identification and cloning of UDP-galactopyranose mutase [J].

Nassau, PM ;

Martin, SL ;

Brown, RE ;

Weston, A ;

Monsey, D ;

McNeil, MR ;

Duncan, K .

JOURNAL OF BACTERIOLOGY, 1996, 178 (04) :1047-1052