A facile one-pot green synthesis and antibacterial activity of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes

被引：455

作者：

Kumar, Dalip ^{[1
]}

Reddy, V. Buchi ^{[1
]}

Sharad, Shashwat ^{[2
]}

Dube, Urvashi ^{[2
]}

Kapur, Suman ^{[2
]}

机构：

[1] Birla Inst Technol & Sci, Chem Grp, Pilani 333031, Rajasthan, India

[2] Birla Inst Technol & Sci, Biol Sci Grp, Pilani 333031, Rajasthan, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 09期

关键词：

Multi-component reaction; Tetrahydro-4H-chromenes; 2-Amino-4H-pyrans; Magnesium oxide; Antibacterial activity; MAGNESIUM-OXIDE; SOLVENT-FREE; SOLID-STATE; DERIVATIVES; KNOEVENAGEL; NITRILES; REAGENTS;

D O I：

10.1016/j.ejmech.2009.04.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A facile one-pot expeditious synthesis of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes has been described under solvent-free conditions using magnesium oxide as a catalyst in very good yields. The reaction catalyst, magnesium oxide was reused and recycled without any loss of activity and product yield. All the synthesized compounds were screened for in vitro antibacterial activity, and compounds 3a, 3b, 3f, 4b, 4c, 4d, 4e and 4g showed complete inhibition of bacterial growth at 128 mu g/mL or less and the rest of the compounds exhibited incomplete inhibition. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：3805 / 3809

页数：5

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