Altered Circadian Food Anticipatory Activity Rhythms in PACAP Receptor 1 (PAC1) Deficient Mice

被引:15
作者
Hannibal, Jens [1 ]
Georg, Birgitte [1 ]
Fahrenkrug, Jan [1 ]
机构
[1] Univ Copenhagen, Bispebjerg Hosp, Fac Hlth Sci, Dept Clin Biochem, Copenhagen, Denmark
来源
PLOS ONE | 2016年 / 11卷 / 01期
关键词
CYCLASE-ACTIVATING POLYPEPTIDE; SUPRACHIASMATIC NUCLEI; NOCTURNAL RODENTS; GANGLION-CELLS; LIGHT; MASKING; CLOCK; ENTRAINMENT; PEPTIDE; LACKING;
D O I
10.1371/journal.pone.0146981
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Light signals from intrinsically photosensitive retinal ganglion cells (ipRGCs) entrain the circadian clock and regulate negative masking. Two neurotransmitters, glutamate and Pituitary Adenylate Cyclase Activating Polypeptide (PACAP), found in the ipRGCs transmit light signals to the brain via glutamate receptors and the specific PACAP type 1 (PAC1) receptor. Light entrainment occurs during the twilight zones and has little effect on clock phase during daytime. When nocturnal animals have access to food only for a few hours during the resting phase at daytime, they adapt behavior to the restricted feeding (RF) paradigm and show food anticipatory activity (FAA). A recent study in mice and rats demonstrating that light regulates FAA prompted us to investigate the role of PACAP/PAC1 signaling in the light mediated regulation of FAA. PAC1 receptor knock out (PAC1-/-) and wild type (PAC1+/+) mice placed in running wheels were examined in a full photoperiod (FPP) of 12:12 h light/dark (LD) and a skeleton photoperiod (SPP) 1:11:1:11 h L:DD:L:DD at 300 and 10 lux light intensity. Both PAC1-/- mice and PAC1+/+ littermates entrained to FPP and SPP at both light intensities. However, when placed in RF with access to food for 4-5 h during the subjective day, a significant change in behavior was observed in PAC1-/- mice compared to PAC1+/+ mice. While PAC1-/- mice showed similar FAA as PAC1+/+ animals in FPP at 300 lux, PAC1-/- mice demonstrated an advanced onset of FAA with a nearly 3-fold increase in amplitude compared to PAC1+/+ mice when placed in SPP at 300 lux. The same pattern of FAA was observed at 10 lux during both FPP and SPP. The present study indicates a role of PACAP/PAC1 signaling during light regulated FAA. Most likely, PACAP found in ipRGCs mediating non-image forming light information to the brain is involved.
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页数:12
相关论文
共 38 条
  • [31] Masking: History, definitions, and measurement
    Mrosovsky, N
    [J]. CHRONOBIOLOGY INTERNATIONAL, 1999, 16 (04) : 415 - 429
  • [32] Photic and Pineal Modulation of Food Anticipatory Circadian Activity Rhythms in Rodents
    Patton, Danica F.
    Parfyonov, Maksim
    Gourmelen, Sylviane
    Opiol, Hanna
    Pavlovski, Ilya
    Marchant, Elliott G.
    Challet, Etienne
    Mistlberger, Ralph E.
    [J]. PLOS ONE, 2013, 8 (12):
  • [33] Robust Food Anticipatory Activity in BMAL1-Deficient Mice
    Pendergast, Julie S.
    Nakamura, Wataru
    Friday, Rio C.
    Hatanaka, Fumiyuki
    Takumi, Toru
    Yamazaki, Shin
    [J]. PLOS ONE, 2009, 4 (03):
  • [34] Peyron C, 1998, J NEUROSCI, V18, P9996
  • [35] Neural basis and biological function of masking by light in mammals: Suppression of melatonin and locomotor activity
    Redlin, U
    [J]. CHRONOBIOLOGY INTERNATIONAL, 2001, 18 (05) : 737 - 758
  • [36] Inhibition of food intake by PACAP in the hypothalamic ventromedial nuclei is mediated by NMDA receptors
    Resch, Jon M.
    Maunze, Brian
    Phillips, Kailynn A.
    Choi, SuJean
    [J]. PHYSIOLOGY & BEHAVIOR, 2014, 133 : 230 - 235
  • [37] Sand A, 2012, PROG RETIN EYE RES
  • [38] Hypothalamic regulation of sleep and circadian rhythms
    Saper, CB
    Scammell, TE
    Lu, J
    [J]. NATURE, 2005, 437 (7063) : 1257 - 1263