Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma

被引：6

作者：

van Schaik, Jeroen E. ^{[1
]}

Kobold, Anna C. Muller ^{[2
]}

van der Laan, Bernard F. A. M. ^{[1
]}

van der Vegt, Bert ^{[3
]}

van Hemel, Bettien M. ^{[3
]}

Plaat, Boudewijn E. C. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, Hanzepl 1, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Lab Med, Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2019年 / 41卷 / 08期

关键词：

FNA; HNSCC; lymph node; SCC-Ag; tumor marker; CANCER; MARKERS; SIZE;

D O I：

10.1002/hed.25733

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background The purpose of this study was to determine the additional diagnostic value of squamous cell carcinoma antigen (SCC-Ag) in cervical lymph node fine needle aspiration (FNA) samples for the detection of regional metastases of head and neck squamous cell carcinoma (HNSCC). Methods In 149 FNA samples of 114 patients, SCC-Ag concentration was retrospectively analyzed and associated with diagnosis to establish a cutoff concentration in relation to sensitivity and specificity of HNSCC detection. Results SCC-Ag was elevated in lymph nodes from patients with HNSCC compared to lymph nodes from other patients (P < 0.01). With 0.3 mu g/L as the cutoff concentration, SCC-Ag has 96% sensitivity for detecting HNSCC. Conclusions SCC-Ag in FNA is a reliable test for detecting HNSCC in cervical lymph nodes.

引用

页码：2561 / 2565

页数：5

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