Childhood central nervous system tumour mortality and survival in Southern and Eastern Europe (1983-2014): Gaps persist across 14 cancer registries

被引：20

作者：

Karalexi, Maria A. ^{[1
]}

Papathoma, Paraskevi ^{[1
]}

Thomopoulos, Thomas P. ^{[1
]}

Ryzhov, Anton ^{[2
]}

Zborovskaya, Anna ^{[3
]}

Dimitrova, Nadya ^{[4
]}

Zivkovic, Snezana ^{[5
]}

Eser, Sultan ^{[6
,7
]}

Antunes, Luis ^{[8
]}

Sekerija, Mario ^{[9
]}

Zagar, Tina ^{[10
]}

Bastos, Joana ^{[11
]}

Demetriou, Anna ^{[12
]}

Agius, Domenic

Cozma, Raluca ^{[13
]}

Coza, Daniela ^{[14
]}

Bouka, Evdoxia ^{[1
]}

Dessypris, Nick ^{[1
]}

Belechri, Maria ^{[1
]}

Dana, Helen ^{[15
]}

Hatzipantelis, Emmanuel ^{[16
]}

Papakonstantinou, Evgenia ^{[17
]}

Polychronopoulou, Sophia ^{[18
]}

Pourtsidis, Apostolos ^{[19
]}

Stiakaki, Eftichia ^{[20
]}

Chatziioannou, Achilles ^{[21
]}

Manolitsi, Katerina ^{[22
]}

Orphanidis, Georgios ^{[23
]}

Papadopoulos, Savvas ^{[24
]}

Papathanasiou, Mathilda ^{[25
]}

Patsouris, Eustratios ^{[26
]}

Sgouros, Spyros ^{[27
]}

Zountsas, Basilios ^{[28
]}

Moschovi, Maria ^{[29
]}

Steliarova-Foucher, Eva ^{[30
]}

Petridou, Eleni Th. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[2] Natl Canc Inst, Natl Canc Registry Ukraine, Kiev, Ukraine

[3] Childhood Canc Subregistry Belarus, Belarusian Res Ctr Pediat Oncol Hematol & Immunol, Minsk, BELARUS

[4] Natl Oncol Hosp, Bulgarian Natl Canc Registry, Sofia, Bulgaria

[5] Inst Publ Hlth Serbia, Belgrade, Serbia

[6] Izmir Canc Registry, Izmir Hub, Izmir, Turkey

[7] Hacettepe Univ, Inst Publ Hlth, Ankara, Turkey

[8] Portuguese Oncol Inst Porto, North Reg Canc Registry Portugal NORTH, Oporto, Portugal

[9] Croatian Inst Publ Hlth, Croatian Natl Canc Registry, Zagreb, Croatia

[10] Canc Registry Republ Slovenia, Inst Oncol, Ljubljana, Slovenia

[11] Inst Portugues Oncol Coimbra Francisco Gentil EPE, Registo Oncol Reg Ctr, Coimbra, Portugal

[12] Minist Hlth, Hlth Monitoring Unit, Cyprus Canc Registry, Nicosia, Cyprus

[13] Inst Publ Hlth, Epidemiol, Timisoara 300226, Romania

[14] Oncol Inst Ion Chiricuta, Reg Canc Registry Cluj, Cluj Napoca, Romania

[15] Mitera Childrens Hosp, Dept Oncol, Athens, Greece

[16] Aristotel Univ Thessaloniki, Dept Pediat 2, AHEPA Gen Hosp, Thessaloniki, Greece

[17] Hippokrateion Hosp, Dept Pediat Hematol & Oncol, Thessaloniki, Greece

[18] Aghia Sophia Childrens Hosp, Dept Pediat Haematol Oncol, Athens, Greece

[19] Pan & Agl Kyriakou Childrens Hosp, Dept Pediat Hematol Oncol, Athens, Greece

[20] Univ Crete, Univ Hosp Heraklion, Dept Pediat Hematol Oncol, Iraklion, Greece

[21] Univ Athens, Sch Med, Aretaie Hosp, Dept Radiol 1, GR-11527 Athens, Greece

[22] Univ Hosp Heraklion, Dept Neurosurg, Iraklion, Crete, Greece

[23] G Gennimatas Gen Hosp, Dept Neurosurg, Athens, Greece

[24] Hygeia Hosp, Dept Pathol, Athens, Greece

[25] Univ Athens, Sch Med, Radiotherapy Unit, Dept Radiol 2, Athens, Greece

[26] Univ Athens, Sch Med, Dept Pathol, Athens 11528, Greece

[27] Mitera Childrens Hosp, Dept Neurosurg, Athens, Greece

[28] St Lukes Hosp, Dept Neurosurg, Thessaloniki, Greece

[29] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Haematol Oncol Unit,Dept Pediat 1, GR-11527 Athens, Greece

[30] Int Agcy Res Canc, Sect Canc Surveillance, F-69372 Lyon, France

来源：

EUROPEAN JOURNAL OF CANCER | 2015年 / 51卷 / 17期

关键词：

Child; Central Nervous System tumours; Survival; Mortality; Urbanisation; Economic status; Health care delivery; Disparities; Cancer registries; TIME TRENDS; SOCIAL DETERMINANTS; HEALTH; LEUKEMIA; COMPARABILITY; ADOLESCENTS; PATTERNS; CHILDREN; QUALITY; ENGLAND;

D O I：

10.1016/j.ejca.2015.08.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: Childhood central nervous system (CNS) tumour registration and control programs in Southern and Eastern Europe remain thin, despite the lethal nature of the disease. Mortality/survival data were assembled to estimate the burden of malignant CNS tumours, as well as the potential role of sociodemographic survival determinants across 14 cancer registries of this region. Methods: Average age-adjusted mortality rates were calculated, whereas time trends were quantified through Poisson and Joinpoint regressions. Kaplan-Meier curves were derived for the maximum and the more recent (10 and 5 year) registration periods. Multivariate Cox regression models were used to assess demographic and disease-related determinants. Results: Variations in mortality (8-16 per million) and survival (5-year: 35-69%) were substantial among the participating registries; in most registries mortality trend was stable, whereas Bulgaria, having the highest starting rate, experienced decreasing annual mortality (-2.4%, p = 0.001). A steep decrease in survival rates was evident before the second year of follow-up. After controlling for diagnostic subgroup, age, gender and diagnostic year, Greece seemed to present higher survival compared with the other contributing registries, although the follow-up period was short. Irrespective of country, however, rural residence was found to impose substantial adverse repercussions on survival (hazard ratio (HR): 1.2, 95% confidence interval (CI): 1.1-1.4). Conclusion: Cross-country mortality and survival variations possibly reflect suboptimal levels of health care delivery and cancer control in some regions of Southern and Eastern Europe, notwithstanding questionable death certification patterns or follow-up procedures. Continuous childhood cancer registration and linkage with clinical data are prerequisite for the reduction of survival inequalities across Europe. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：2665 / 2677

页数：13

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