Metabolic Alterations Related to Glioma Grading Based on Metabolomics and Lipidomics Analyses

被引：28

作者：

Yu, Di ^{[1
,2
]}

Xuan, Qiuhui ^{[1
,2
]}

Zhang, Chaoqi ^{[3
,4
]}

Hu, Chunxiu ^{[1
]}

Li, Yanli ^{[1
]}

Zhao, Xinjie ^{[1
]}

Liu, Shasha ^{[3
]}

Ren, Feifei ^{[3
,4
]}

Zhang, Yi ^{[3
,4
]}

Zhou, Lina ^{[1
]}

Xu, Guowang ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Zhengzhou Univ, Biotherapy Ctr, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China

[4] Zhengzhou Univ, Ctr Canc, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China

来源：

METABOLITES | 2020年 / 10卷 / 12期

基金：

中国国家自然科学基金;

关键词：

glioma; metabolomics; lipidomics; grading; short-chain acylcarnitines; lysophosphatidylethanolamines; MALIGNANT GLIOMA;

D O I：

10.3390/metabo10120478

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gliomas are the most aggressive phenotypes of brain tumors and are classified into four grades according to the malignancy degree by the World Health Organization. Metabolic profiling can provide an overview of metabolic reprogramming at a specific stage of tumor initiation and development. Studies about metabolic alterations related to different grades of gliomas are helpful to understand the molecular mechanism for progression of glioma. In the current study, metabolomics and lipidomics analyses based on chromatography-mass spectrometry were performed on different grades of glioma tissues. Differential metabolites between glioma and para-tumor tissues were studied and used as the basis to explore metabolic alterations related to glioma grading. It was found that short-chain acylcarnitines were elevated, whereas lysophosphatidylethanolamines (LPEs) were decreased in high-grade gliomas. Furthermore, the gene expression of short/branched-chain acyl-coenzyme dehydrogenase (ACADSB), which is involved in fatty acid oxidation, was found down-regulated with glioma progression by analyzing related genes and pathways. In addition, LPE metabolism showed a significant difference among different grades of gliomas. These important metabolic pathways related to glioma progression may provide potential clues for further study on the mechanisms and treatment of glioma.

引用

页码：1 / 11

页数：11

共 33 条

[1] Adult Glioblastoma [J].

Alexander, Brian M. ;

Cloughesy, Timothy F. .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (21) :2402-+

[2] CARNITINE - METABOLISM AND FUNCTIONS [J].

BREMER, J .

PHYSIOLOGICAL REVIEWS, 1983, 63 (04) :1420-1480

[3] Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns [J].

Chace, DH ;

Kalas, TA ;

Naylor, EW .

CLINICAL CHEMISTRY, 2003, 49 (11) :1797-1817

[4] Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells [J].

Chen, Jian ;

Mckay, Renee M. ;

Parada, Luis F. .

CELL, 2012, 149 (01) :36-47

[5] Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[6] Actively personalized vaccination trial for newly diagnosed glioblastoma [J].

Hilf, Norbert ;

Kuttruff-Coqui, Sabrina ;

Frenzel, Katrin ;

Bukur, Valesca ;

Stevanovic, Stefan ;

Gouttefangeas, Cecile ;

Platten, Michael ;

Tabatabai, Ghazaleh ;

Dutoit, Valerie ;

van der Burg, Sjoerd H. ;

Straten, Per Thor ;

Martinez-Ricarte, Francisco ;

Ponsati, Berta ;

Okada, Hideho ;

Lassen, Ulrik ;

Admon, Arie ;

Ottensmeier, Christian H. ;

Ulges, Alexander ;

Kreiter, Sebastian ;

von Deimling, Andreas ;

Skardelly, Marco ;

Migliorini, Denis ;

Kroep, Judith R. ;

Idorn, Manja ;

Rodon, Jordi ;

Piro, Jordi ;

Poulsen, Hans S. ;

Shraibman, Bracha ;

McCann, Katy ;

Mendrzyk, Regina ;

Loewer, Martin ;

Stieglbauer, Monika ;

Britten, Cedrik M. ;

Capper, David ;

Welters, Marij J. P. ;

Sahuquillo, Juan ;

Kiesel, Katharina ;

Derhovanessian, Evelyna ;

Rusch, Elisa ;

Bunse, Lukas ;

Song, Colette ;

Heesch, Sandra ;

Wagner, Claudia ;

Kemmer-Bruck, Alexandra ;

Ludwig, Joerg ;

Castle, John C. ;

Schoor, Oliver ;

Tadmor, Arbel D. ;

Green, Edward ;

Fritsche, Jens .

NATURE, 2019, 565 (7738) :240-+

[7] Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics [J].

Huang, Qiang ;

Tan, Yexiong ;

Yin, Peiyuan ;

Ye, Guozhu ;

Gao, Peng ;

Lu, Xin ;

Wang, Hongyang ;

Xu, Guowang .

CANCER RESEARCH, 2013, 73 (16) :4992-5002

[8] Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS [J].

Jarmusch, Alan K. ;

Pirro, Valentina ;

Baird, Zane ;

Hattab, Eyas M. ;

Cohen-Gadol, Aaron A. ;

Cooks, R. Graham .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (06) :1486-1491

[9] Short-chain acyl-coenzyme A dehydrogenase deficiency [J].

Jethva, Reena ;

Bennett, Michael J. ;

Vockley, Jerry .

MOLECULAR GENETICS AND METABOLISM, 2008, 95 (04) :195-200

[10] Metabolic Variations between Low-Grade and High-Grade Gliomas-Profiling by 1H NMR Spectroscopy [J].

Jothi, Jayalakshmi ;

Janardhanam, Vanisree Arambakkam ;

Krishnaswamy, Rama .

JOURNAL OF PROTEOME RESEARCH, 2020, 19 (06) :2483-2490

← 1 2 3 4 →