Identification of Novel Predictive Markers for the Prognosis of Pancreatic Ductal Adenocarcinoma

被引：35

作者：

Jiang, Bing ^{[1
]}

Gu, Yonghong ^{[1
]}

Chen, Yuxiang ^{[2
]}

机构：

[1] Cent S Univ, Dept Pathol, Xiangya Hosp 3, Changsha 410008, Hunan, Peoples R China

[2] Cent S Univ, Hepatobiliary & Enter Surg Res Ctr, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China

来源：

CANCER INVESTIGATION | 2014年 / 32卷 / 06期

关键词：

Pancreatic ductal adenocarcinoma; prognosis; klotho; IGF-1; receptor; methylation; miR-504; TUMOR-SUPPRESSOR P53; LYSOPHOSPHATIDIC ACID; NEGATIVE REGULATION; KLOTHO EXPRESSION; MALIGNANT ASCITES; POOR-PROGNOSIS; CANCER CELLS; DISEASE; PROGRESSION; MICRORNAS;

D O I：

10.3109/07357907.2014.905586

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study demonstrated that klotho gene expression was significantly lower whereas miR-504 and phospho-IGF-1R levels were significantly higher in PDAC than in normal pancreatic tissues. miR-504 level significantly correlated with klotho mRNA and promoter methylation level in PDACs. Loss of Klotho protein expression, klotho promoter hypermethylation, high miR-504 levels, and high phospho-IGF-1R levels significantly correlated with poor survival, high clinical and pathological stages in PDAC patients. The demethylation reagent and miR-504 inhibitor increased klotho gene expression, invasion, and migration in BxPC-3 and Panc-1 cells. Klotho is a tumor suppressor whose expression in PDAC correlated with progression and prognosis of PDAC.

引用

页码：218 / 225

页数：8

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