Exploration of a β-cyclodextrin clicked chiral stationary phase in high-performance liquid chromatography

被引：16
作者：
Zhang, Shaopeng [1 ]
Wang, Huanhuan [1 ]
Tang, Jian [1 ]
Wang, Wei [2 ]
Tang, Weihua [1 ]
机构：
[1] Nanjing Univ Sci & Technol, Minist Educ, Key Lab Soft Chem & Funct Mat, Nanjing 210094, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Dept Analyt Chem, Nanjing 211198, Jiangsu, Peoples R China
来源：
ANALYTICAL METHODS | 2014年 / 6卷 / 07期
基金：
中国国家自然科学基金; 高等学校博士学科点专项科研基金;
关键词：
SEPARATION; RECOGNITION; CHEMISTRY;
D O I：
10.1039/c3ay42193g
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The baseline enantioseparation of 19 racemic drugs including ondansetron, citalopram, galanthamine base, pregabalin, timolol, atenolol, tropicamide, ephedrine hydrochloride, flavanoids and aryl alcohols has been successfully achieved with a cyclodextrin clicked chiral stationary phase in high performance liquid chromatography. The best separation results were presented under optimized conditions. The effect of organic modifiers including methanol and acetonitrile on the enantioseparation of racemates was also studied. Chiral resolutions of 4.19 and 4.42 were achieved for citalopram and tropicamide, respectively.
引用
收藏
页码：2034 / 2037
页数：4
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