Population genetics and the evolution of virulence in Staphylococcus aureus

被引：26
作者：
Chua, Kyra Y. L. [1 ,3 ,4 ]
Howden, Benjamin P. [1 ,2 ,3 ,4 ]
Jiang, Jhih-Hang [2 ]
Stinear, Timothy [1 ]
Peleg, Anton Y. [2 ,5 ,6 ]
机构：
[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia
[2] Monash Univ, Dept Microbiol, Clayton, Vic 3800, Australia
[3] Austin Hlth, Dept Infect Dis, ACIR, Heidelberg, Vic 3084, Australia
[4] Austin Hlth, Dept Microbiol, Heidelberg, Vic 3084, Australia
[5] Alfred Hosp, Dept Infect Dis, Melbourne, Vic 3181, Australia
[6] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA
来源：
INFECTION GENETICS AND EVOLUTION | 2014年 / 21卷
基金：
英国医学研究理事会;
关键词：
S; aureus; Molecular epidemiology; Methicillin-resistant S. aureus; Multi-locus sequence typing; PANTON-VALENTINE LEUKOCIDIN; COMPLETE GENOME SEQUENCE; FIELD GEL-ELECTROPHORESIS; RESTRICTION-MODIFICATION SYSTEM; CATABOLIC MOBILE ELEMENT; TOXIC-SHOCK-SYNDROME; METHICILLIN-RESISTANT; PATHOGENICITY ISLANDS; ALPHA-HEMOLYSIN; NUCLEOTIDE-SEQUENCE;
D O I：
10.1016/j.meegid.2013.04.026
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Staphylococcus aureus is one of the most important human pathogens, causing life-threatening infection in the community and hospital setting. The population genetics of S. aureus and the evolution of virulence is the focus of this review. We describe the various techniques in determining S. aureus population structure and discuss the insights gained from whole genome sequencing of various S. aureus strains. The emergence of community-acquired, methicillin-resistant S. aureus provides a framework for the discussion on evolution of virulence, and the role of horizontal gene transfer in the development of virulence and antibiotic resistance is explored. The knowledge generated from population genetics has the potential to inform strategies to assist in the prevention or treatment of this highly successful human pathogen. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：554 / 562
页数：9
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