Simultaneous Differential Pulse Voltammetric Determination of Sulfamethoxazole and Trimethoprim on a Boron-Doped Diamond Electrode

The performance of hydrogen- (HT) and oxygen-terminated (OT) boron-doped diamond (BDD) electrodes (electrochemically pretreated) on the simultaneous differential pulse voltammetric determination of sulfamethoxazole and trimethoprim in pharmaceutical products is presented. Under the optimum analytical experimental conditions, the HT-BDD electrode presented two well-defined oxidation peaks at 920 and 1100 mV vs. Ag/AgCl for sulfamethoxazole and trimethoprim, respectively. On the other hand, when the OT-BDD electrode was used, the sulfamethoxazole oxidation current peak was decreased twenty fold. The calculated LOD values for sulfamethoxazole and trimethoprim using the HT-BDD electrode were 3.65 mu g L-1 and 3.92 mu g L-1, respectively The results obtained in the simultaneous determination of sulfamethoxazole and trimethoprim in three different commercial formulations were similar to those obtained using it standard HPLC method at 95% confidence level.