Chemical constituents from Curcuma longa L. and their inhibitory effects of nitric oxide production

被引：17

作者：

Yuan, Ting ^{[1
]}

Zhang, Cuiyun ^{[1
]}

Qiu, Chongyue ^{[1
]}

Xia, Guiyang ^{[1
]}

Wang, Fei ^{[1
]}

Lin, Bin ^{[2
]}

Li, Hua ^{[1
,3
]}

Chen, Lixia ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Sch Tradit Chinese Mat Med, Wuya Coll Innovat,Minist Educ, Shenyang, Liaoning, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang, Liaoning, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan, Hubei, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 16期

关键词：

Curcuma longa L; sesquiterpenoids; nitric oxide; CONTROLLED-TRIAL; SESQUITERPENES; COMPLICATIONS; CURCUMINOIDS; CANDIDATE; RHIZOMES; CELLS;

D O I：

10.1080/14786419.2017.1354185

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new bisabolane-type sesquiterpenoid, turmerone Q (1), along with six known compounds (2-7), were isolated from the rhizomes of Curcuma longa L.The structural elucidation of the new compound was conducted using H-1 NMR, C-13 NMR, HSQC, HMBC and NOESY spectroscopic analyses. The absolute configuration of 1 was elucidated by comparison of the experimental and calculated ECD spectra.The anti-inflammatory effects of 1-7 were evaluated through lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages assays, and compounds 6 and 7 showed potent inhibitory activity against NO production. [GRAPHICS] .

引用

页码：1887 / 1892

页数：6

共 19 条

[1] A new antiplatelet diarylheptanoid from Alpinia blepharocalyx [J].