Stable and selective recognition of three base pairs in the parallel triple-helical DNA binding motif

被引：45

作者：

Buchini, S ^{[1
]}

Leumann, CJ ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 30期

关键词：

antigenes; DNA recognition; DNA triplex; intercalation; oligonucleotides;

D O I：

10.1002/anie.200460159

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Modifying bases in parallel-triplex-forming oligonucleotides with a 2′-O-amino-ethyl backbone enabled an extended DNA triplex recognition code to be developed for use in the control of gene expression. Removal of the oxygen atom at C4 of thymine transforms a donor/acceptor base into a double acceptor base and redirects recognition from A-T to strong and highly selective C-G recognition (see scheme).

引用

页码：3925 / 3928

页数：4

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