The Purinergic P2X7 Receptor-NLRP3 Inflammasome Pathway: A New Target in Alcoholic Liver Disease?

被引：20

作者：

Le Dare, Brendan ^{[1
,2
]}

Ferron, Pierre-Jean ^{[1
]}

Gicquel, Thomas ^{[1
,2
]}

机构：

[1] Univ Rennes, CHU Rennes, NuMeCan Inst Nutr Metab & Canc, INSERM,INRAE, F-35000 Rennes, France

[2] Rennes Univ Hosp, Forens & Toxicol Lab, 2 Rue Henri Le Guilloux, F-35033 Rennes, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 04期

关键词：

alcoholic-related liver disease; NLRP3; inflammasome; purinergic receptor; macrophage; Kupffer cell; interleukin-1β NLRP3; INFLAMMASOME; OXIDATIVE STRESS; NALP3; ACTIVATION; ETHANOL; PATHOGENESIS; FIBROSIS; FAMILY; INJURY; DEHYDROGENASE;

D O I：

10.3390/ijms22042139

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The World Health Organization has estimated that approximately 3 million deaths are attributable to alcohol consumption each year. Alcohol consumption is notably associated with the development and/or progression of many non-communicable inflammatory diseases-particularly in the liver. Although these alcoholic liver diseases were initially thought to be caused by the toxicity of ethanol on hepatocytes, the latest research indicates Kupffer cells (the liver macrophages) are at the heart of this "inflammatory shift". Purinergic signaling (notably through P2X7 receptors and the NLRP3 inflammasome) by Kupffer cells appears to be a decisive factor in the pathophysiology of alcoholic liver disease. Hence, the modulation of purinergic signaling might represent a new means of treating alcoholic liver disease. Here, we review current knowledge on the pathophysiology of alcoholic liver diseases and therapeutic perspectives for targeting these inflammatory pathways.

引用

页码：1 / 13

页数：13

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