Effect of 4-aminopyridine and 3,4-diaminopyridine on guinea-pig isolated ileum

被引：4

作者：

Velasco, A ^{[1
]}

Maroto, M ^{[1
]}

Duenas, A ^{[1
]}

Carvajal, A ^{[1
]}

delaGandara, FF ^{[1
]}

Nieto, A ^{[1
]}

机构：

[1] FAC MED,DEPT SURG,E-47005 VALLADOLID,SPAIN

来源：

JOURNAL OF AUTONOMIC PHARMACOLOGY | 1997年 / 17卷 / 01期

关键词：

D O I：

10.1046/j.1365-2680.1997.00441.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

1 4-Aminopyridine and 3,4-diaminopyridine produced concentration-dependent contraction on guinea-pig isolated ileum incubated in Tyrode solution. The EC50 values were 1.14 x 10(-4) and 1.39 x 10(-4) M, respectively. 2 Calcium channel blockers such as verapamil, diltiazem, nifedipine, flunarizine, and lanthanum chloride antagonized the contracting effect induced by 4-aminopyridine and 3,4-diaminopyridine in guinea-pig isolated ileum. 3 Diazoxide and atropine sulphate behaved similarly as antagonists of the contracting effect induced by 4-aminopyridine and 3,4-diaminopyridine in guinea-pig isolated ileum. 4 It is concluded that the aminopyridines exert their effects through the release of acetylcholine from parasympathetic nerve terminals.

引用

页码：53 / 57

页数：5

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