Cytotoxic phenolic compounds isolated from the fruits of Macaranga denticulata

被引：6

作者：

Tran Nguyen Vu Le ^{[1
,2
]}

Bich Ngan Truong ^{[1
,2
]}

Thi Phuong Le ^{[1
]}

Litaudon, Marc ^{[3
]}

Dang Thach Tran ^{[4
]}

Van Minh Chau ^{[1
]}

Huong Doan Thi Mai ^{[1
,2
]}

Van Cuong Pham ^{[1
,2
]}

机构：

[1] VAST, Inst Marine Biochem, Adv Ctr Bioorgan Chem, Hanoi, Vietnam

[2] Grad Univ Sci & Technol, VAST, Fac Chem, Hanoi, Vietnam

[3] Univ Paris Saclay, CNRS, UPR 2301, ICSN, Gif Sur Yvette, France

[4] Univ Ind Vinh, Inst Appl Sci & Technol, Vinh, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 11期

关键词：

Macaranga denticulata; Euphorbiaceae; geranylated flavonoid; 3 '-dehydroxy-solophenol C; cytotoxic activity; PRENYLATED FLAVONOIDS; CONSTITUENTS; PROPOLIS;

D O I：

10.1080/14786419.2019.1639175

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new modified geranylated flavonoid, 3 '-dehydroxy-solophenol C (1), along with 17 known compounds (2-18) were isolated from the fruits of Macaranga denticulata. Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR and 2D-NMR. The new geranylated flavonoid 1 showed a moderate cytotoxic activity against the A549 cell line with IC50 value of 16.0 mu M. Compound 9 showed the highest cytotoxic activities against KB, HepG2, Lu-1 and MCF7 cell lines with IC50 values of 0.6, 0.8, 1.3 and 1.2 mu M, respectively. [GRAPHICS] .

引用

页码：1861 / 1868

页数：8

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