Fatherhood contributes to increased hippocampal spine density and anxiety regulation in California mice

被引:23
作者
Glasper, Erica R. [1 ,2 ]
Hyer, Molly M. [2 ]
Katakam, Jhansi [1 ]
Harper, Robyn [1 ]
Ameri, Cyrus [1 ]
Wolz, Thomas [1 ]
机构
[1] Univ Maryland, Dept Psychol, 2123M Biol Psychol Bldg,4094 Campus Dr, College Pk, MD 20742 USA
[2] Univ Maryland, Program Neurosci & Cognit Sci, College Pk, MD 20742 USA
来源
BRAIN AND BEHAVIOR | 2016年 / 6卷 / 01期
关键词
Anxiety; dendritic spines; fatherhood; DEPRESSION-LIKE BEHAVIOR; PATERNAL BEHAVIOR; REPRODUCTIVE EXPERIENCE; MATERNAL SEPARATION; ADULT NEUROGENESIS; POSTPARTUM PERIOD; DENDRITIC SPINES; PEROMYSCUS; MOUSE; VASOPRESSIN;
D O I
10.1002/brb3.416
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Introduction: Parenting alters the hippocampus, an area of the brain that undergoes significant experience-induced plasticity and contributes to emotional regulation. While the relationship between maternal care and hippocampal neuroplasticity has been characterized, the extent to which fatherhood alters the structure and function of the hippocampus is far less understood. Methods: Here, we investigated to what extent fatherhood altered anxiety regulation and dendritic morphology of the hippocampus using the highly paternal California mouse (Peromyscus californicus). Results: Fathers spent significantly more time on the open arms of the elevated plus maze, compared to non-fathers. Total distance traveled in the EPM was not changed by paternal experience, which suggests that the increased time spent on the open arms of the maze indicates decreased anxiety-like behavior. Fatherhood also increased dendritic spine density of granule cells in the dentate gyrus and basal dendrites of pyramidal cells in area CA1 of the hippocampus. Conclusions: These findings parallel those observed in maternal rodents, suggesting that the hippocampus of fathers and mothers respond similarly to offspring.
引用
收藏
页码:1 / 6
页数:6
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