Purification of fluorous Mitsunobu reactions by liquid-liquid extraction

被引：15

作者：

Curran, Dennis P. ^{[1
]}

Bajpai, Reena ^{[1
]}

Sanger, Elizabeth ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2006年 / 348卷 / 12-13期

关键词：

diazodicarboxylates; fluorous; liquid-liquid extraction; Mitsunobu reaction;

D O I：

10.1002/adsc.200606187

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Solvent tuning and partition coefficient measurements have identified suitable reagent and solvent combinations for the purification of fluorous Mitsunobu reaction products. The crude reaction mixtures are partitioned between 2/1 HFE-7100/FC-72 and DMF/10% water to provide reagent (fluorous) and product (organic) fractions.

引用

页码：1621 / 1624

页数：4

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