Novel Bile Acids from Bear Bile Powder and Bile of Geese

被引：24
作者：
Bi, Dan [1 ]
Chai, Xing-Yun [1 ]
Song, Yue-Lin [1 ]
Lei, Yu [1 ]
Tu, Peng-Fei [1 ]
机构：
[1] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2009年 / 57卷 / 05期
关键词：
Selenaretos thibetanus; Anser anser domesticus; bile acid; PRIMARY BILIARY-CIRRHOSIS; URSODEOXYCHOLIC ACID; IDENTIFICATION;
D O I：
10.1248/cpb.57.528
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new bile acids, tauroselocholic acid (1) and tauroansocholic acid (2), a new natural bile acid, cygnocholic acid (3) were respectively isolated from bear bile powder Selenaretos thibetanus CUVIER and bile of geese Anser anser domesticus, together with seven known compounds. By spectrum analysis of MS, 1D and 2D NMR, the structures of the new compounds were elucidated as 3 alpha,7 alpha, 9 alpha-trihydroxy-5 beta-cholan-24-oic acid N-[2-sulfoethyl] amide (1), 3 alpha,5,7 alpha-trihydroxy-5 beta-cholan-24-oic acid N-[2-sulfoethyl] amide (2) and 3 alpha,7 alpha,15 alpha-trihydroxy-5 beta-cholan-24-oic acid (3).
引用
收藏
页码：528 / 531
页数：4
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