The antioxidant properties of salicylate derivatives: A possible new mechanism of anti-inflammatory activity

被引：40

作者：

Borges, Rosivaldo S. ^{[1
,2
]}

Castle, Steven L. ^{[2
]}

机构：

[1] Fed Univ Para, Inst Ciencias Saude, Fac Farm, BR-66075110 Belem, PA, Brazil

[2] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 21期

关键词：

Salicylate derivatives; Anti-inflammatory; Antioxidant mechanism; DFT; DPPH center dot; GENTISIC ACID; 5-AMINOSALICYLIC ACID; ACETYLSALICYLIC-ACID; ASPIRIN METABOLITE; OXIDATIVE STRESS; COLON-CANCER; IN-VITRO; INHIBITION; POTENT; DESIGN;

D O I：

10.1016/j.bmcl.2015.07.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and antioxidant evaluation by DPPH center dot scavenging of a series of salicylic acid derivatives is described. Gentisic acid and its ester, amide, and amino analogs possess more radical scavenging capacity than salicylic acid and other salicylate derivatives. This property can possibly provide an additional pathway for anti-inflammatory activity through either single electron or hydrogen atom transfer, leading to a new strategy for the design of anti-inflammatory agents. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：4808 / 4811

页数：4

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