Vagal Stimulation in Heart Failure

被引：54

作者：

De Ferrari, Gaetano M. ^{[1
,2
]}

机构：

[1] Fdn IRCCS Policlin San Matteo, Dept Cardiol, I-27100 Pavia, Italy

[2] Fdn IRCCS Policlin San Matteo, Cardiovasc Clin Res Ctr, I-27100 Pavia, Italy

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2014年 / 7卷 / 03期

关键词：

Heart failure; Vagal activity; Vagus nerve stimulation; Anti-inflammatory activity; Reperfusion damage; Ventricular fibrillation; VAGUS NERVE-STIMULATION; PERMEABILITY TRANSITION PORE; LEFT-VENTRICULAR FUNCTION; CONSCIOUS DOGS; BAROREFLEX SENSITIVITY; RATE-VARIABILITY; INFARCT SIZE; MITOCHONDRIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; CANINE MODEL;

D O I：

10.1007/s12265-014-9540-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure (HF) is accompanied by an autonomic imbalance that is almost always characterized by both increased sympathetic activity and withdrawal of vagal activity. Experimentally, vagal stimulation has been shown to exert profound antiarrhythmic activity and to improve cardiac function and survival in HF models. A open-label pilot clinical study in 32 patients with chronic HF has shown safety and tolerability of chronic vagal stimulation associated with subjective (improved quality of life and 6-min walk test) and objective improvements (reduced left ventricular systolic volumes and improved left ventricular ejection fraction). Three larger clinical studies, including a phase III trial are currently ongoing and will evaluate the clinical role of this new approach.

引用

页码：310 / 320

页数：11

共 77 条

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