Emerging immunotherapies for malignant glioma: from immunogenomics to cell therapy

被引：46

作者：

Dunn, Gavin P. ^{[1
,2
]}

Cloughesy, Timothy F. ^{[3
,4
,5
]}

Maus, Marcela, V ^{[4
,6
,7
]}

Prins, Robert M. ^{[5
,8
,9
]}

Reardon, David A. ^{[7
,10
,11
]}

Sonabend, Adam M. ^{[12
]}

机构：

[1] Washington Univ, Dept Neurol Surg, Sch Med, St Louis, MO 63110 USA

[2] Washington Univ, Andrew M & Jane M Bursky Ctr Human Immunol & Immu, Sch Med, St Louis, MO 63110 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med & Mol Pharmacol, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA

[6] Massachusetts Gen Hosp, Cellular Immunotherapy Program, Canc Ctr, Charlestown, MA USA

[7] Harvard Med Sch, Boston, MA 02115 USA

[8] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA

[9] Parker Inst Canc Immunotherapy, San Francisco, CA USA

[10] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[11] Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA

[12] Northwestern Univ, Dept Neurol Surg, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

NEURO-ONCOLOGY | 2020年 / 22卷 / 10期

关键词：

cancer immunogenomics; CNS immunosurveillance; glioblastoma; neoantigen; personalized vaccine; MISMATCH REPAIR DEFICIENCY; EXOME ANALYSIS REVEALS; MAP KINASE ACTIVATION; CAR-T-CELLS; CHECKPOINT BLOCKADE; CANCER IMMUNOGENOMICS; CTLA-4; BLOCKADE; B-CELL; MASS-SPECTROMETRY; PD-1;

D O I：

10.1093/neuonc/noaa154

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As immunotherapy assumes a central role in the management of many cancers, ongoing work is directed at understanding whether immune-based treatments will be successful in patients with glioblastoma (GBM). Despite several large studies conducted in the last several years, there remain no FDA-approved immunotherapies in this patient population. Nevertheless, there are a range of exciting new approaches being applied to GBM, all of which may not only allow us to develop new treatments but also help us understand fundamental features of the immune response in the central nervous system. In this review, we summarize new developments in the application of immune checkpoint blockade, from biomarker-driven patient selection to the timing of treatment. Moreover, we summarize novel work in personalized immune-oncology by reviewing work in cancer immunogenomics-driven neoantigen vaccine studies. Finally, we discuss cell therapy efforts by reviewing the current state of chimeric antigen receptorT-cell therapy.

引用

页码：1425 / 1438

页数：14

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