Increasing phylogenetic resolution still informative for Y chromosomal studies on West-European populations

被引：20

作者：

Larmuseau, M. H. D. ^{[1
,2
,3
]}

Vanderheyden, N. ^{[1
]}

Van Geystelen, A. ^{[1
,4
]}

van Oven, M. ^{[5
]}

Kayser, M. ^{[5
]}

Decorte, R. ^{[1
,2
]}

机构：

[1] UZ Leuven, Lab Forens Genet & Mol Archaeol, Louvain, Belgium

[2] Katholieke Univ Leuven, Dept Imaging & Pathol, Louvain, Belgium

[3] Katholieke Univ Leuven, Lab Biodivers & Evolutionary Genom, Dept Biol, Louvain, Belgium

[4] Katholieke Univ Leuven, Dept Biol, Lab Socioecol & Social Evolut, Louvain, Belgium

[5] Erasmus MC Univ, Med Ctr Rotterdam, Dept Forens Mol Biol, Rotterdam, Netherlands

来源：

FORENSIC SCIENCE INTERNATIONAL-GENETICS | 2014年 / 9卷

关键词：

Discrimination power; Population structure; Y-SNPs; Flanders; Genetic genealogy; Y-chromosomal phylogeny; DIFFERENTIATION; GENETICS; GENEALOGY; PACKAGE; REGION; TESTS; SNPS; TREE; AGE;

D O I：

10.1016/j.fsigen.2013.04.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Many Y-chromosomal lineages which are defined in the latest phylogenetic tree of the human Y chromosome by the Y Chromosome Consortium (YCC) in 2008 are distributed in (Western) Europe due to the fact that a large number of phylogeographic studies focus on this area. Therefore, the question arises whether newly discovered polymorphisms on the Y chromosome will still be interesting to study Western Europeans on a population genetic level. To address this question, the West-European region of Flanders (Belgium) was selected as study area since more than 1000 Y chromosomes from this area have previously been genotyped at the highest resolution of the 2008 YCC-tree and coupled to in-depth genealogical data. Based on these data the temporal changes of the population genetic pattern over the last centuries within Flanders were studied and the effects of several past gene flow events were identified. In the present study a set of recently reported novel Y-SNPs were genotyped to further characterize all those Flemish Y chromosomes that belong to haplogroups G, R-M269 and T. Based on this extended Y-SNP set the discrimination power increased drastically as previous large (sub-) haplogroups are now subdivided in several non-marginal groups. Next, the previously observed population structure within Flanders appeared to be the result of different gradients of independent sub-haplogroups. Moreover, for the first time within Flanders a significant East-West gradient was observed in the frequency of two R-M269 lineages, and this gradient is still present when considering the current residence of the DNA donors. Our results thus suggest that an update of the Y-chromosomal tree based on new polymorphisms is still useful to increase the discrimination power based on Y-SNPs and to study population genetic patterns in more detail, even in an already well-studied region such as Western Europe. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：179 / 185

页数：7

共 34 条

[1] A map of human genome variation from population-scale sequencing [J].

Altshuler, David ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Collins, Francis S. ;

De la Vega, Francisco M. ;

Donnelly, Peter ;

Egholm, Michael ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Knoppers, Bartha M. ;

Lander, Eric S. ;

Lehrach, Hans ;

Mardis, Elaine R. ;

McVean, Gil A. ;

Nickerson, DebbieA. ;

Peltonen, Leena ;

Schafer, Alan J. ;

Sherry, Stephen T. ;

Wang, Jun ;

Wilson, Richard K. ;

Gibbs, Richard A. ;

Deiros, David ;

Metzker, Mike ;

Muzny, Donna ;

Reid, Jeff ;

Wheeler, David ;

Wang, Jun ;

Li, Jingxiang ;

Jian, Min ;

Li, Guoqing ;

Li, Ruiqiang ;

Liang, Huiqing ;

Tian, Geng ;

Wang, Bo ;

Wang, Jian ;

Wang, Wei ;

Yang, Huanming ;

Zhang, Xiuqing ;

Zheng, Huisong ;

Lander, Eric S. ;

Altshuler, David L. ;

Ambrogio, Lauren ;

Bloom, Toby ;

Cibulskis, Kristian ;

Fennell, Tim J. ;

Gabriel, Stacey B. .

NATURE, 2010, 467 (7319) :1061-1073

[2]

[Anonymous], ADV TOPICS FORENSIC

[3]

ATHEY WT, 2006, J GENET GENEAL, V2, P34

[4] Micro-geographical differentiation in Northern Iberia revealed by Y-chromosomal DNA analysis [J].

Brion, M ;

Quintans, B ;

Zarrabeitia, M ;

Gonzalez-Neira, A ;

Salas, A ;

Lareu, V ;

Tyler-Smith, C ;

Carracedo, A .

GENE, 2004, 329 :17-25

[5] The peopling of Europe and the cautionary tale of Y chromosome lineage R-M269 [J].

Busby, George B. J. ;

Brisighelli, Francesca ;

Sanchez-Diz, Paula ;

Ramos-Luis, Eva ;

Martinez-Cadenas, Conrado ;

Thomas, Mark G. ;

Bradley, Daniel G. ;

Gusmao, Leonor ;

Winney, Bruce ;

Bodmer, Walter ;

Vennemann, Marielle ;

Coia, Valentina ;

Scarnicci, Francesca ;

Tofanelli, Sergio ;

Vona, Giuseppe ;

Ploski, Rafal ;

Vecchiotti, Carla ;

Zemunik, Tatijana ;

Rudan, Igor ;

Karachanak, Sena ;

Toncheva, Draga ;

Anagnostou, Paolo ;

Ferri, Gianmarco ;

Rapone, Cesare ;

Hervig, Tor ;

Moen, Torolf ;

Wilson, James F. ;

Capelli, Cristian .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2012, 279 (1730) :884-892

[6] Subtyping of Y-chromosomal haplogroup E-M78 (E1b1b1a) by SNP assay and its forensic application [J].

Caratti, S. ;

Gino, S. ;

Torre, C. ;

Robino, C. .

INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 2009, 123 (04) :357-360

[7] Y chromosome diversity, human expansion, drift, and cultural evolution [J].

Chiaroni, Jacques ;

Underhill, Peter A. ;

Cavalli-Sforza, Luca L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (48) :20174-20179

[8]

Cloet M, 1989, TIEN BIJDRAGEN LOKAL, P291

[9] Strong intra- and inter-continental differentiation revealed by Y chromosome SNPs M269, U106 and U152 [J].

Cruciani, Fulvio ;

Trombetta, Beniamino ;

Antonelli, Cheyenne ;

Pascone, Roberto ;

Valesini, Guido ;

Scalzi, Valentina ;

Vona, Giuseppe ;

Melegh, Bela ;

Zagradisnik, Boris ;

Assum, Guenter ;

Efremov, Georgi D. ;

Sellitto, Daniele ;

Scozzari, Rosaria .

FORENSIC SCIENCE INTERNATIONAL-GENETICS, 2011, 5 (03) :E49-E52

[10]

Debrabandere F, 2003, WOORDENBOEK FAMILIEN

← 1 2 3 4 →