Treatment Refusal and Abandonment Remain Major Concerns Despite Good Outcomes with Multi-Modality Management in Pediatric Medulloblastoma: Experience from a Cancer Center in Eastern India

被引：4

作者：

Das, Anirban ^{[1
]}

Achari, Rimpa Basu ^{[2
]}

Sena, Saugata ^{[4
]}

Krishnan, Shekhar ^{[1
]}

Bhattacharyya, Arpita ^{[1
]}

Zameer, Lateef ^{[3
]}

机构：

[1] Tata Med Ctr, Dept Paediat Haematol Oncol, 14 Major Arterial Rd EW, Kolkata 700160, W Bengal, India

[2] Tata Med Ctr, Dept Radiat Oncol, Kolkata, W Bengal, India

[3] Tata Med Ctr, Dept Histopathol, Kolkata, W Bengal, India

[4] Tata Med Ctr, Dept Radiol, Kolkata, W Bengal, India

来源：

INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY | 2019年 / 40卷

关键词：

Brain tumor; defaulter; ototoxicity; posterior fossa; AVERAGE-RISK MEDULLOBLASTOMA; CHILDREN; CHEMOTHERAPY;

D O I：

10.4103/ijmpo.ijmpo_213_17

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Context: Survival in medulloblastoma, the most common pediatric brain tumor, has lagged behind in developing countries in comparison to the West. Aim: The aim of this study was to analyze the clinical profile and outcome in a cancer center in Eastern India. Methods: Twenty-nine children were retrospectively analyzed over 6 years. Results: Vomiting (79%), headache (69%), and unsteadiness (55%) were the presenting complaints. The majority (67%) had classical histology. High-risk (HR) disease (61.6%) exceeded average-risk (AR) (38.4%) disease in numbers. Treatment-refusal (27.6%) and abandonment (6.9%) were major concerns. Four-year EFS was 81% and 52%, excluding and including refusal/abandonment, respectively. There was no relapse/ progression among AR patients. Four-year EFS in HR was 63%. Posterior fossa syndrome (37.5%), febrile neutropenia (29%), and ototoxicity (16.7%) were the main treatment-related morbidities.

引用

页码：S13 / S15

页数：3