The effects of body temperature control on cytokine production in a rat model of ventilator-induced lung injury

被引：30

作者：

Morita, Yasumasa ^{[1
]}

Oda, Shigeto ^{[1
]}

Sadahiro, Tomohito ^{[1
]}

Nakamura, Masataka ^{[1
]}

Oshima, Taku ^{[1
]}

Otani, Shunsuke ^{[1
]}

Hirasawa, Hiroyuki ^{[1
]}

机构：

[1] Chiba Univ, Dept Emergency & Crit Care Med, Grad Sch Med, Chiba, Japan

来源：

CYTOKINE | 2009年 / 47卷 / 01期

基金：

日本学术振兴会;

关键词：

Ventilator-induced lung injury; Cytokine; Hypothermia; Normothermia; Hyperthermia; SURVIVING SEPSIS CAMPAIGN; RESPIRATORY-DISTRESS-SYNDROME; END-EXPIRATORY PRESSURE; MODERATE HYPOTHERMIA; INFLAMMATORY RESPONSE; INTERNATIONAL GUIDELINES; MECHANICAL VENTILATION; MILD HYPOTHERMIA; SEPTIC SHOCK; ORGAN INJURY;

D O I：

10.1016/j.cyto.2009.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background and purpose: Injurious ventilation with high peak inspiratory pressure (PIP) is known to cause systemic inflammatory response through cytokine production. This study was performed to examine whether body temperature could regulate cytokine production in ventilator-induced lung injury (VILI) model. Methods: After performing anesthesia, tracheostomy, and catheter insertion, rats were ventilated with 17 cm, H2O of PIP in the low-pressure (LP) group or 35 cm H2O in the high-pressure (HP) group. Then, each group was divided into three subgroups; hyperthermia (39 degrees C), normothermia (37 degrees C), and hypothermia (34 degrees C) group. Six groups were observed for 6 h. Results: Plasma levels of pro-inflammatory cytokines, TNF-a and IL-6 at 1 h after the start of observation were highest in 39 degrees C-HP group and were lowest in 34 degrees C-HP group. Furthermore, sustained high plasma levels of IL-6 were observed only in 39 degrees C-HP group. In contrast, plasma levels of anti-inflammatory cytokine, IL-10 at 1 h were highest in 34 degrees C-HP group, and lowest in 39 degrees C-HP group. Conclusion: The body temperature significantly affects cytokine production in a model of VILI. Body temperature control may be a potentially effective therapeutic modality to regulate cytokine production in VILI. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：48 / 55

页数：8

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