Bioluminescence Probe for Detecting Hydrogen Sulfide in Vivo

被引：99

作者：

Ke, Bowen ^{[1
]}

Wu, Wenxiao ^{[2
]}

Liu, Wei ^{[1
]}

Liang, Hong ^{[1
]}

Gong, Deying ^{[1
]}

Hu, Xiaotong ^{[1
]}

Li, Minyong ^{[2
]}

机构：

[1] Sichuan Univ, West China Hosp, Translat Neurosci Ctr, Lab Anaesthesiol & Crit Care Med, Chengdu 610041, Sichuan, Peoples R China

[2] Shandong Univ, Sch Pharm, Key Lab Chem Biol MOE, Dept Med Chem, Jinan 250012, Shandong, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2016年 / 88卷 / 01期

基金：

中国国家自然科学基金;

关键词：

FLUORESCENT-PROBES; CELL; LUCIFERIN; ACTIVATION; DISEASE; ROLES; H2S;

D O I：

10.1021/acs.analchem.5b03636

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Considering that hydrogen sulfide (H2S) is an endogenous signaling molecule involved in numerous biological processes, a method for monitoring H2S as a powerful tool for investigating its complicated functions and mechanisms is urgently demanded. Herein, a bioluminescent turn-on probe was reported based on caged strategy for the detection of H2S in vitro and in vivo. This probe will help us understand the intricate contribution of H2S to a variety of physiological and pathological processes.

引用

页码：592 / 595

页数：4

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