The Role of ARV Associated Adverse Drug Reactions in Influencing Adherence Among HIV-Infected Individuals: A Systematic Review and Qualitative Meta-Synthesis

被引：41

作者：

Li, Haochu ^{[1
,2
]}

Marley, Gifty ^{[1
]}

Ma, Wei ^{[1
]}

Wei, Chongyi ^{[3
]}

Lackey, Mellanye ^{[2
]}

Ma, Qingyan ^{[2
]}

Renaud, Francois ^{[4
]}

Vitoria, Marco ^{[4
]}

Beanland, Rachel ^{[4
]}

Doherty, Meg ^{[4
]}

Tucker, Joseph D. ^{[2
,5
]}

机构：

[1] Shandong Univ, Sch Publ Hlth, Jinan, Peoples R China

[2] Univ North Carolina Chapel Hill, Inst Global Hlth & Infect Dis, UNC Project China, Chapel Hill, NC 27514 USA

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[4] WHO, HIV Dept, Geneva, Switzerland

[5] UNC Project China, Guangdong Prov Skin Dis & STI Control, 2 Lujing Rd, Guangzhou 510095, Guangdong, Peoples R China

来源：

AIDS AND BEHAVIOR | 2017年 / 21卷 / 02期

关键词：

Adverse drug reaction; Adherence; Qualitative meta-synthesis; HIV; Antiretroviral; ANTIRETROVIRAL THERAPY ADHERENCE; MEDICATION ADHERENCE; BARRIERS; FACILITATORS; HAART; WOMEN; PERSPECTIVES; NONADHERENCE; CHALLENGES; ATTITUDES;

D O I：

10.1007/s10461-016-1545-0

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Poor adherence remains a major barrier to achieving the clinical and public health benefits of antiretroviral drugs (ARVs). A systematic review and qualitative meta-synthesis was conduct to evaluate how ARV adverse drug reactions may influence ARV adherence. Thirty-nine articles were identified, and 33 reported that ARV adverse drug reactions decreased adherence and six studies found no influence. Visually noticeable adverse drug reactions and psychological adverse reactions were reported as more likely to cause non-adherence compared to other adverse drug reactions. Six studies reported a range of adverse reactions associated with EFV-containing regimens contributing to decreased adherence. Informing HIV-infected individuals about ARV adverse drug reactions prior to initiation, counselling about coping mechanisms, and experiencing the effectiveness of ARVs on wellbeing may improve ARV adherence.

引用

页码：341 / 351

页数：11

共 69 条

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