Abnormal Muscularization of Intra-acinar Pulmonary Arteries in Two Cases Presenting as Sudden Infant Death

被引：4

作者：

Zainun, Khairul ^{[1
,2
]}

Hope, Kirsten ^{[1
]}

Nicholson, Andrew G. ^{[3
,4
]}

Cohen, Marta C. ^{[1
]}

机构：

[1] Sheffield Childrens Hosp Fdn Trust, Dept Histopathol, Western Bank, Sheffield S10 2TH, S Yorkshire, England

[2] Hosp Sultanah Aminah, Dept Forens Med, Johor Baharu, Johore, Malaysia

[3] Royal Brompton & Harefield Hosp NHS Fdn Trust, Dept Histopathol, London, England

[4] Imperial Coll, Natl Heart & Lung Div, London, England

来源：

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY | 2017年 / 20卷 / 01期

关键词：

acinar arteries; autopsy; persistent pulmonary hypertension of newborn; SIDS; sudden unexpected death in infancy; HYPERTENSION; NEWBORN; MECHANISMS;

D O I：

10.1177/1093526616689311

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Abnormal muscularization of acinar arteries is the hallmark of persistent pulmonary hypertension of newborn (PPHN), an uncommon disease with high rate of morbidity and mortality. PPHN presents with signs of respiratory distress immediately following birth. We herein report 2 cases presenting as a witnessed sudden unexpected death in the late neonatal period, preceded by respiratory deterioration and in whom the presence of abnormal muscularization of the acinar pulmonary arteries was reminiscent of PPHN. The significance of this report is twofold: to increase the awareness among pediatricians and pathologists of this feature that can present in some cases of Sudden Unexpected Death in Infancy/Sudden Infant Death Syndrome, and to highlight the importance of performing a thorough autopsy in order to identify the abnormality.

引用

页码：49 / 53

页数：5

共 16 条

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