Hybrid multiphoton and optoacoustic microscope

被引：45

作者：

Tserevelakis, George J.

Soliman, Dominik

Omar, Murad

Ntziachristos, Vasilis ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Biol & Med Imaging, D-80290 Munich, Germany

来源：

OPTICS LETTERS | 2014年 / 39卷 / 07期

关键词：

PHOTOACOUSTIC MICROSCOPY; OPTICAL COHERENCE; IN-VIVO; TOMOGRAPHY; PROTEINS; NEURONS;

D O I：

10.1364/OL.39.001819

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present a hybrid microscope combining multiphoton microscopy incorporating second-harmonic generation contrast and optical-resolution optoacoustic (photoacoustic) microscopy. We study the relative performance of the two systems and investigate the complementarity of contrast by demonstrating the label-free imaging capabilities of the hybrid microscope on zebrafish larvae ex vivo, concurrently visualizing the fish musculature and melanocytes. This implementation can prove useful in multiparametric microscopy studies, enabling broader information to be collected from biological specimens. (C) 2014 Optical Society of America

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页码：1819 / 1822

页数：4

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