Remote and Persistent Alterations in Glutamate Receptor Subunit Composition Induced by Spreading Depolarizations in Rat Brain

被引：5

作者：

Barhorst, Kinsey A. ^{[1
]}

Alfawares, Yara ^{[2
]}

McGuire, Jennifer L. ^{[3
]}

Danzer, Steve C. ^{[4
,5
,6
,7
]}

Hartings, Jed A. ^{[3
,8
]}

Ngwenya, Laura B. ^{[3
,8
,9
]}

机构：

[1] Univ Cincinnati, Coll Med, Cincinnati, OH USA

[2] Univ Cincinnati, Cincinnati, OH USA

[3] Univ Cincinnati, Dept Neurosurg, 231 Albert Sabin Way,MSB 5251, Cincinnati, OH 45267 USA

[4] Cincinnati Childrens Hosp Med Ctr, Dept Anesthesia, Cincinnati, OH 45229 USA

[5] Univ Cincinnati, Dept Anesthesia, Cincinnati, OH USA

[6] Cincinnati Childrens Hosp Med Ctr, Ctr Pediat Neurosci, Cincinnati, OH USA

[7] Univ Cincinnati, Dept Pediat, Cincinnati, OH USA

[8] Univ Cincinnati, Collaborat Res Acute Neurol Injury CRANI, Cincinnati, OH USA

[9] Univ Cincinnati, Dept Neurol & Rehabil Med, Cincinnati, OH USA

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2022年 / 42卷 / 04期

关键词：

Spreading depolarization; Spreading depression; Glutamate receptor; Plasticity; Brain injury; NMDA RECEPTORS; DEPRESSION; INJURY; PLASTICITY;

D O I：

10.1007/s10571-020-01000-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Spreading depolarizations (SDs) are massive breakdowns of ion homeostasis in the brain's gray matter and are a necessary pathologic mechanism for lesion development in various injury models. However, injury-induced SDs also propagate into remote, healthy tissue where they do not cause cell death, yet their functional long-term effects are unknown. Here we induced SDs in uninjured cortex and hippocampus of Sprague-Dawley rats to study their impact on glutamate receptor subunit expression after three days. We find that both cortical and hippocampal tissue exhibit changes in glutamate receptor subunit expression, including GluA1 and GluN2B, suggesting that SDs in healthy brain tissue may have a role in plasticity. This study is the first to show prolonged effects of SDs on glutamate signaling and has implications for neuroprotection strategies aimed at SD suppression.

引用

页码：1253 / 1260

页数：8

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